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🆕✍️ What GLP-1 drug price is cost neutral to Medicare? Seemingly around $140/month
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20 September
19 September
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korrents.com
Time spent on bureaucratic paperwork is a real economic cost even though it doesn't appear in government budgets.Their words
it is simply ridiculous that a ruinously expensive policy can be budget-neutral if the expense consists of wasted time rather than wasted money. But that's still a cost!
17 September
16 September
15 September
14 September
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Their words
Technologies are not neutral, but political. Money is indeed one of the incentives, but not the only one. A mixture of millennialism, eugenics, search for utopia and for a spread of the specie beyond the confines of the Earth, are all elements we find among the founders’ views.
12 September
11 September
10 September
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korrents.com
Universities and their administrations should remain ideologically neutral toward faculty's political viewsTheir words
An institution must remain neutral with regard to the ideological beliefs of its faculty.
8 September
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korrents.com
Removing a concept from a mind can damage unrelated systems or push the mind toward incompetence or insanity.Their words
empirically concepts can get their tentacles into weird places, and removing one can topple seemingly unrelated systems or push a mind nonspecifically in the direction of incompetence or insanity.
6 September
5 September
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Their words
We can’t count on surrogate blood markers to guide the results of cardiovascular clinical outcome trials.
The Coronary Artery Inflammation Controversyerictopol.substack.com
4 September
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Lovedsponsoredrcmnd.app
Skilhunt H150V4 5000KTheir words
The Skilhunt H150V4 5000K headlamp is an outstanding headlamp. It's great for being neutral white, high CRI, running an included 14500 cell or AA, and having a great user interface. The price is fairly reasonable because of all those reasons and the great build quality!
3 September
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korrents.com
A coding-agent company should not train its own model: it has to stay neutral ground for models to compete on.Their words
people ask us if we'll train our own model and the answer currently is no 1. we are too dumb to 2. there's plenty of other well funded efforts 3. we need to remain a neutral ground for models to battle
2 September
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Their words
You definitely will NOT get a body you see on fitness Instagram or in Hollywood 99% of those people are on gear and not natty!
1 September
31 August
27 August
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korrents.com
Killing suspected drug smugglers at sea without trial is murder, because smuggling is not a capital offence.Their words
Even if it turned out that they were drug smugglers, as claimed, and even if it turned out that they were bringing drugs to the United States, a dubious proposition, the penalty for smuggling drugs is not summary execution.
25 August
20 August
From one piece From Restoring Sight to Reimagining the Brain, with Max Hodak 3 beliefs, in the piece's order there
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korrents.com
Humanity is not good enough at molecular biology to make drugs that restore vision or hearing or stop Parkinson's.Their words
People have spent huge amounts of time and money looking for drugs to restore vision or to restore hearing or to stop Parkinson's or to to help paralyzed people move again. Understanding the like the biology and the molecular detail required to make a drug has been very difficult. Humanity just isn't that good at that, to be totally honest.
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Their words
Yeah, I mean I think BCI is a category kind of like how pharma is a category. I think sometimes you I I'll talk to VCs and like, "Oh, we have a BCI bet." I'm like, "Do you have a drug bet? You made one bet on a drugs? Like that's that's how you think about the category?"
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korrents.com
Putting a device into the brain works in an hour, which makes it far more amenable to biology than drug discovery.Their words
It's like if I put electrodes in M1, you will probably be using a computer in an hour. Um and so it's just it's easier, it's more amenable to biology in many ways.
19 August
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Usesrcmnd.app
Claude CodeTheir words
Like seemingly everyone else at the end of last year, I began messing around with Claude Code, and have since made a small handful of apps that I really do use all the time.
17 August
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Their words
open models are still incredibly useful, but fill a long-tail ecosystem relative to the closed counterparts that have monopoly ownership stakes in the most valuable areas like knowledge work collaboration, drug discovery, SWE, etc.
12 August
9 August
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Their words
The Sea Peoples did not invade lands to claim them as their own, or extract treasure or slaves to bring back to their homeland. They seemingly torched the great capitals of the Bronze Age just to watch them burn.
7 August
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Their words
It gives you these effect sizes that you just don't really see in medicine. Like if you have a patient on on a dopamineergic drug for Parkinson's that works for some period of time, but it's a it's a relatively small effect after a little while. You turn on a deep brain stimulator and a patient goes from not being able to hold a cup of water to being able to write cursive in like 10 seconds.
6 August
29 July
22 July
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Their words
The two seemingly contradictory trends connect, because the relatively low rate of productive investment leaves European industry vulnerable to its most vigorous competitors whose firms are contending with an even more deflationary macroeconomic situation at home in China.
21 July
From one piece Intelligence is not the main bottleneck 4 beliefs, in the piece's order there
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korrents.com
Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be.Their words
In biomedicine we have a problem called target herding: most companies chase the same biological targets because they are de-risked, which means we explore far less of the biological space than we could.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
That is mostly in the realm of chemistry and is intrinsically far more tractable and predictable; given a validated target, good teams usually reach a decent molecule.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
The patent system then further disincentivizes companies from taking target risk, because it rewards novel chemical matter, not novel biology.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
Take Eroom’s Law: the number of new drugs approved per dollar of R&D has fallen for decades, even as our scientific tools have grown vastly more powerful, the exact opposite of what the existence of more raw capability would predict.
Intelligence is not the main bottleneckwritingruxandrabio.com
8 July
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korrents.com
Recorded crime partly measures policing: a neighbourhood policed harder produces more crime in the statistics.Their words
Particularly with gun and drug crimes, communities with more aggressive policing tend to produce more crimes in part because law enforcement polices them more aggressively.
A guide to racism in the criminal justice systemradleybalko.substack.com
4 July
From one piece Metformin and cancer: active surveillance needed 3 beliefs, in the piece's order there
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korrents.com
Metformin is not a general-purpose anti-cancer or anti-ageing drug, and healthy people should not take it as one.Their words
MAST adds to a growing body of evidence suggesting that metformin is not a general-purpose anticancer drug.
Metformin and cancer: active surveillance neededpeterattiamd.com
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Their words
we now have multiple trials confirming that metformin interferes with your ability to reap the adaptive benefits of exercise, which is the most powerful broad-based longevity intervention available to us today
Metformin and cancer: active surveillance neededpeterattiamd.com
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Their words
That’s a lesson we could all learn about our approach to supplements and even drugs: not to fall for hazy promises that a single molecule will deliver vaguely-defined benefits for all aging persons, but to demand rigorous evidence for well-defined benefits for well-defined problems in well-defined populations.
Metformin and cancer: active surveillance neededpeterattiamd.com
30 June
27 June
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Their words
These failures are a strong signal that HDL-C is not the variable we should be trying to manipulate.
24 June
20 June
16 June
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Their words
And everyone says, "Why are they liking this man? He is a cruel murdering tyrant." And the answer is for the first time in generations, they have had something close to fair justice.
28 May
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Their words
So it's no wonder that the artists and designers whose livelihoods are threatened by it have begun moving aggressively in the opposite direction, toward the scrawled, the sloppy, the seemingly mistake-riddled.
27 May
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Their words
If you get your positioning right, the world just keeps handing you wins that you didn't even expect. So like we never predicted this exact scenario but like our fundamental understanding of the position was right. like if if there is a neutral party, all these companies with billions of dollars will kind of use a neutral party to advance their own like company's interests.
13 April
20 March
15 March
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Likedrcmnd.app
Truthear x Crinacle - ZERO:REDTheir words
Great neutral sound signature, perfect for gaming and listening EDMs
28 February
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Their words
Trials serve two distinct functions: validation — confirming whether a drug works and is safe — and learning, or generating biological data to refine our understanding of a disease, a compound, and the relationship between the two.
21 January
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Their words
Sleep – high quality sleep is the world’s #1 longevity drug.
17 January
26 December 2025
29 November 2025
9 November 2025
14 October 2025
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Their words
the shift from 50th to 99th percentile earnings has no negative effect on women’s fertility, and unearned income for women has a neutral-to-positive effect
Falling Fertility Is Not About Opportunity Costlymanstone.substack.com
19 September 2025
From one piece Norman Ohler: Hitler, Nazis, Drugs, WW2, Blitzkrieg, LSD, MKUltra & CIA | Lex Fridman Podcast #481 5 beliefs, in the piece's order there
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Their words
So the Navy hired the shoe runners unit from the SS, paid them money, and then gave them drugs, different kinds of drug combinations, methamphetamine combined with cocaine and chewing gum and all kinds of things. So this is a big thing, you know. And there are documents to it.
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korrents.com
The Neanderthals lost to us because they had no drug culture — they were too sober for the future.Their words
And I think, a lot of evidence kind of points to it that we were able to develop our consciousness in a better way than the Neanderthals, who did not have a drug culture. They were basically too sober for the future. We assimilated them.
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korrents.com
LSD is not a truth drug and never could be — it takes you toward your own truth, not out of it.Their words
They miserably failed because LSD… Is not the truth drug. LSD maybe leads you closer to your own truth, because when suddenly the default mode network receives less energy and other parts of the brain think more, and the neuroplasticity of the brain is enhanced and stimulated, you might understand something about your life.
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korrents.com
An entire army was prescribed methamphetamine by written decree, with dosages, intervals and side effects specified.Their words
And he gave lectures in front of the officers, and he wrote a stimulant decree where a whole army is prescribed a drug, in this case methamphetamine. How much should be taken? At what intervals? What are the side effects?
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Their words
One thing that changed was that Eukodal was not available anymore, so the drug that Hitler actually had become physically addicted to was suddenly not available anymore. This had to do with the bombardment of the Merck company, the factory in December 1944. British bombers destroyed the production facilities.
16 September 2025
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Their words
The value of research is usually in telling you which of two plausible theories is true, or which advice from different, seemingly sensible approaches works best.
11 June 2025
28 May 2025
From one piece What Was The War on Drugs? Part V 2 beliefs, in the piece's order there
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korrents.com
Drug enforcement cut casual use and barely touched heavy users, who account for most of the drugs consumed.Their words
But by the available evidence, the War on Drugs was far less successful at reducing use among the “hard core” of users, mostly meaning people addicted to their drug of choice.
What Was The War on Drugs? Part Vthecausalfallacy.substack.com
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Their words
Drug offenders never accounted for a particularly large fraction of the U.S. prison population, peaking at about 22 percent of state prisoners in 1990.
What Was The War on Drugs? Part Vthecausalfallacy.substack.com
13 January 2025
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Their words
This is the global race of our lives. Now, some countries are going to make AI breakthroughs and export them… Others will end up buying those breakthroughs and importing them. The question is – which of those will Britain be? AI maker or AI taker?
1 December 2024
20 October 2024
17 September 2024
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Their words
Another challenge for Class II biotechs is that even if you have a nifty computational drug discovery platform, you are still often bottlenecked by the rest of the drug development process. It takes 1,000 (or more!) small steps to advance a drug through discovery, development, and past the regulators.
23 December 2023
From one piece The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it 4 beliefs, in the piece's order there
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Their words
Because patents have fixed term lengths, with small extensions to compensate for the year or so when the drug is under regulatory review, drug developers are incentivized to go after conditions where clinical trials can be completed quickly, all else being equal.
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Their words
Biology is unpredictable, especially when the immune system is involved, and there is no guarantee that a drug that appears safe in animals will be safe in humans.
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Their words
The most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make.
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Their words
In reality, the productivity crisis in the pharmaceutical industry is the culmination of decades of just about every aspect of drug discovery and development getting gradually harder and more expensive.
30 October 2023
1 October 2023
25 May 2023
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Their words
But we do not have enough data and we do not have enough insight to use AI/ML to pick better targets that have a higher chance of succeeding in the clinic.
9 May 2023
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Dislikedrcmnd.app
Apple MailTheir words
unlike Apple Mail, which seemingly uses shortcuts that made sense in 1995 and refuses to change.
17 February 2023
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Their words
The biggest issue is probably that we don’t control neutral networks enough to be able to ensure AI doesn’t harm humans. We can’t even control AI to not reveal internal prompts.
1 June 2022
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Their words
The lower the neutral rate, the smaller the fiscal and welfare costs and the larger the welfare benefits of debt and deficits.
28 October 2020
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Likedaffiliate linkrcmnd.app
DecodedTheir words
Decoded is a semi-autobiographical book that tells Jay-Z's story growing up and finding success in hip hop. It also helps you deeply understand the inner-city ghetto struggles (Jay was actually a drug dealer until age 27). In organized sections of hand picked songs with RapGenius-style lyric explanations (note: Decoded came first), you see through his eyes the difficult choices he and so many others faced while listening to some of his best tracks.
1 May 2020
From one piece Why Are Clinical Trials So Complicated? 2 beliefs, in the piece's order there
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Their words
You cannot wing it when you're giving a drug to human beings.
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Their words
The procedures that have grown up around drug development are a sort of Chesterton's Fence: we shouldn't pull them down without considering the reasons why they were put up.
4 February 2020
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Their words
As generative drug analoging grows in importance, it's going to be crucial for people to make the entire training set available in detail when such work is published.
31 October 2018
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Their words
There is nothing about a foundation that is inherently good, neutral, or charitable, simply because they have a 501(c) status.
30 October 2012
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Lovedrcmnd.app
HaskellTheir words
I've gradually became a big fan of Haskell; I feel it makes me write much more solid code that is much easier to maintain and refactor. But the best part is there are seemingly no end of things to learn in the Haskell space.
3 August 2012
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Their words
Products fulfilling a purpose are like tools. They are neither decorative objects nor works of art. Their design should therefore be both neutral and restrained, to leave room for the user’s self-expression.
8 March 2012
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Their words
I think that this is insufficiently appreciated outside of the drug business. Nothing goes away unless it's well and truly superseded.
5 March 2012
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Recommendsrcmnd.app
Memoir of HungaryTheir words
Sándor Márai is one of the great Hungarian novelists. He was in Hungary during the war, and left in 1948. This book is about a neutral intellectual's encounter with communism, and it records what he saw as it happened.
1 October 1975
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