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Saloni Dattani x.com
Most people have never heard of siRNA, but it’s going to change the face of medicine. https://t.co/RLP1pxuICA Much drug development today involves developing chemicals to fit into proteins and block them. But this almost never turns out as planned: many drug candidates get broken down in the body, interfere with other proteins and cause toxic side effects, or fail to be absorbed at all. The majority of proteins are considered undruggable, because they lack a pocket for drugs to bind, or they are ‘intrinsically disordered’, without coherent structure. What if, instead of trying to block the pr…
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I mean I think like if you look at uh my colleagues work on say alpha fold that was a very specific model for uh protein folding and it was highly successful um and was able to really handle that domain quite well so that all of a sudden you now have this amazing tool and model that can give you answers to questions about proteins and their structure um really effectively um but it's not a general model it's a very specific one and there are other I domains where that kind of approach can work really well. Uh maybe in material science or chip design or things like that that uh will enable you to leverage the capabilities of a very accurate but but niche model uh to do things that are hard today.
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Once we can accurately predict cancer 5+ years ahead, the era of primary prevention will go into high gear.
4 September 2025
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