Eric Topol
Cardiologist and founder of the Scripps Research Translational Institute; writes Ground Truths on biomedical research, and wrote Super Agers and Deep Medicine.
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Where they publish
Newsletter Ground Truths His newsletter reading new biomedical research. Has a feed.
Posts several times a week going through new papers on ageing, AI in medicine, vaccines and diagnostics, usually with the figures reproduced.
Recent
- The Big Holes in Wearable Heart Rate Variability And Readiness Scores 19 Sept 2026 A Gaping Lack of Evidence for Health Benefits
- Marios Georgakis: Why Did Two Major Clinical Trials for Heart Disease Fail? 14 Sept 2026 A conversation with Prof Marios Georgakis
- The Coronary Artery Inflammation Controversy 5 Sept 2026 How Two Large Outcome Trials Based on Surrogate Metrics Failed
Show 17 more
- Two Landmark Studies Challenge Dogma About our Brain Immune Cells and Aging 30 Aug 2026 Lead Authors Julia Belk and Nathan Zemke Discuss and Translate their Findings
- Deborah Cohen: The Wellness-Industrial Complex 23 Aug 2026 The Sick Until Proven Healthy Trap
- Why Our Memory Slips After Age 50 12 Aug 2026 Landmark independent studies challenge longstanding dogma for brain aging
- Sarah Urbut: Predicting Your Health Arc 4 Aug 2026 Watch now (54 mins) | Sarah Urbut MD, PhD Takes Us Through Her Landmark Nature Paper
- Patrick Hsu: How Is AI Catalyzing Life Science? 20 Jul 2026 Patrick Hsu Comes Back to Ground Truths
- Medicine is Moving From Calendars to Clocks 12 Jul 2026 Proteins Tell How Fast Our Organs and Cells Are Ticking
- Aaron Newman: A Breakthrough Blood Test for Cancer 3 Jul 2026 Prof Aaron Newman and I discuss a blood test to assess the tumor microenvironment
- Elisa Port: Discuss THE BREAST ADVICE Book 26 Jun 2026 A recording from Eric Topol's live video with annotations below
- Agentic AI Comes to Medicine 17 Jun 2026 Expansion of Capabilities With Two New Medical AI Models
- A New Path to Preventing Cancer 13 Jun 2026 A Landmark Study Showing the Way Forward
- Helen Pearson: What Constitutes Real Medical Evidence? 6 Jun 2026 A conversation with Helen Pearson on her new book BEYOND BELIEF
- The Remarkable Proliferation of Cancer Immunotherapies 24 May 2026 On a Path to Interception—Prevention Vaccines
- Assessment of the Hantavirus with Prof Donald Milton 14 May 2026 A recording from Eric Topol's live video
- Joanna Stern: An AI Immersion for 365 Days 13 May 2026 Joanna Stern's I AM NOT A ROBOT new book
- The Paradox of Medical AI Implementation 3 May 2026 From Missed Opportunities to Missing Evidence
- Roxanne Khamsi: We Are All Genetic Mosaics 25 Apr 2026 Roxanne Khamsi's phenomenal book BEYOND INHERITANCE on the critical impact of our acquired, somatic mutations for health and disease
- Sebastian Mallaby: The Infinity Machine 19 Apr 2026 A NYT Bestseller and masterpiece on how AI Grew Up by Sebastian Mallaby
Link verified 20 Sept 2026. Recent items update automatically from the channel.
Beliefs
Korrents What they believe 9 beliefs — each backed by an exact quote.
Each is a — compiled by korrents.com, not by them: the one-line wordings are korrents', the quotes are theirs.
Recent
A drug that moves a surrogate blood marker in the right direction cannot be assumed to prevent heart attacks and strokes.
We can’t count on surrogate blood markers to guide the results of cardiovascular clinical outcome trials.
The Coronary Artery Inflammation Controversy Said 5 Sept 2026
Inflammation's role in coronary artery disease is proven, not hypothetical; what is missing is a safe and potent way to reduce it.
The “inflammation hypothesis” is not a hypothesis.
The Coronary Artery Inflammation Controversy Said 5 Sept 2026
A coronary calcium score of zero does not mean the arteries are free of disease, and in a younger adult it is far weaker reassurance than it looks.
We know that arteries with a calcium (CAC) score of zero can be highly inflamed, and that high CAC scores are not necessarily high-risk for cardiovascular events.
The Coronary Artery Inflammation Controversy Said 5 Sept 2026
Show 6 more
Brain ageing is not gradual wear: around midlife the brain's original immune cells are replaced by inflammatory cells that came from the blood.
The original brain microglia (Micro1) are replaced by transformed monocytes (Micro 2) that are highly inflammatory.
Why Our Memory Slips After Age 50 Said 12 Aug 2026
Our organs and cell types age at different rates, so a single chronological age is an illusion.
It also turns out our organs age at a different pace.
Medicine is Moving From Calendars to Clocks Said 12 Jul 2026
The brain and the immune system act as the master regulators of ageing: when they age at a normal pace, survival over the following 15 years is near total.
Accordingly, the brain and immune system have the appearance of master regulators of the aging process.
Medicine is Moving From Calendars to Clocks Said 12 Jul 2026
Measurable, modifiable biological age at the organ and cell level is the most important advance yet in the science of human ageing.
I believe this represents the most important advance we have yet seen in the science of human aging.
Medicine is Moving From Calendars to Clocks Said 12 Jul 2026
Nobody should buy a direct-to-consumer biological age test today: they are sold expensively without standardisation or demonstrated reliability.
I would suggest not buying any of these tests.
Medicine is Moving From Calendars to Clocks Said 12 Jul 2026
Cancer can be predicted from blood proteins years before diagnosis, and that is what will finally make primary prevention of cancer possible.
Once we can accurately predict cancer 5+ years ahead, the era of primary prevention will go into high gear.
A New Path to Preventing Cancer Said 13 Jun 2026
Beliefs others hold too
A coronary calcium score of zero does not mean the arteries are free of disease, and in a younger adult it is far weaker reassurance than it looks. 2 hold this
We know that arteries with a calcium (CAC) score of zero can be highly inflamed, and that high CAC scores are not necessarily high-risk for cardiovascular events.
The Coronary Artery Inflammation Controversy Said 5 Sept 2026
What is a korrent?
A korrent is a belief a person has stated in their own words: one sentence stating the claim, backed by a quote and a source, kept at korrents.com.
Under a name here, the quoted block is what they actually said. The korrent beneath it is the claim those words support, in korrents' wording — tap it to see the record, its source, and who else holds it.
Nobody here wrote their own korrents. They are compiled from public statements, and a person can change their mind, which is recorded too.
Feed
As its own page →Hiding
19 September
14 September
5 September
From one piece The Coronary Artery Inflammation Controversy 3 beliefs · erictopol.substack.com
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Their words
We know that arteries with a calcium (CAC) score of zero can be highly inflamed, and that high CAC scores are not necessarily high-risk for cardiovascular events.
The Coronary Artery Inflammation Controversyerictopol.substack.com
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Their words
The “inflammation hypothesis” is not a hypothesis.
The Coronary Artery Inflammation Controversyerictopol.substack.com
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Their words
We can’t count on surrogate blood markers to guide the results of cardiovascular clinical outcome trials.
The Coronary Artery Inflammation Controversyerictopol.substack.com
30 August
23 August
12 August
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Their words
The original brain microglia (Micro1) are replaced by transformed monocytes (Micro 2) that are highly inflammatory.
4 August
20 July
12 July
From one piece Medicine is Moving From Calendars to Clocks 4 beliefs · erictopol.substack.com
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Their words
I would suggest not buying any of these tests.
Medicine is Moving From Calendars to Clockserictopol.substack.com
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Their words
I believe this represents the most important advance we have yet seen in the science of human aging.
Medicine is Moving From Calendars to Clockserictopol.substack.com
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Their words
Accordingly, the brain and immune system have the appearance of master regulators of the aging process.
Medicine is Moving From Calendars to Clockserictopol.substack.com
+ 1 more
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korrents.com
Our organs and cell types age at different rates, so a single chronological age is an illusion.Their words
It also turns out our organs age at a different pace.
Medicine is Moving From Calendars to Clockserictopol.substack.com
3 July
26 June
17 June
13 June
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Their words
Once we can accurately predict cancer 5+ years ahead, the era of primary prevention will go into high gear.
6 June
24 May
14 May
13 May
3 May
25 April
19 April
Nothing matches.
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