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Their words
It's isn't just to people with ADHD that this happens. Some tasks inherently take a certain amount of time. An appointment that breaks the afternoon into two blocks of time could leave you with no block long enough to complete a task.
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Elliot Hershberg Newsletter
The the words it uses that this site has seen least often elsewhere. Posts are matched on those words alone — nothing here is a summary of this one.
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18 September
17 September
11 September
10 September
3 September
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Lovedrcmnd.app
GPT-6 AstraTheir words
GPT-6 Astra represents a step-function change in model capability for interactive reasoning problems. It scores 66% on ARC-AGI-3 using our standard harness, and nearly 100% with a continuous conversation harness and custom compaction, at a cost of roughly $360 per game.
2 September
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Their words
I worry a lot about reliances on continuity failing at exactly the most dangerous time.
1 September
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korrents.com
Curing disease is not worth it if the price is the permanent deprecation of most human beings' existence.Their words
As someone coming from a biology background, who considers “curing disease” as a very noble mission, I still believe that the vague promise of “curing disease” is fundamentally not worth it if it comes with a form of permanent deprecation of most humans’ existence.
24 August
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Their words
The left is on a project to enforce equality, despite biology and markets. The goal of equality gives claim to the moral high ground, but contradicting biology and markets requires censorship and violence, which makes the whole project immoral.
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Their words
it was only about 15 years ago I started beginning to be aware that there may be a an important biology underlying motivation and when that biology goes wrong, it can lead to loss of motivation and even pathological apathy.
23 August
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Their words
/Z, /J, and /MT are not levels on a performance slider. They change restartability, buffering, and concurrency.
20 August
From one piece From Restoring Sight to Reimagining the Brain, with Max Hodak 2 beliefs, in the piece's order there
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korrents.com
Humanity is not good enough at molecular biology to make drugs that restore vision or hearing or stop Parkinson's.Their words
People have spent huge amounts of time and money looking for drugs to restore vision or to restore hearing or to stop Parkinson's or to to help paralyzed people move again. Understanding the like the biology and the molecular detail required to make a drug has been very difficult. Humanity just isn't that good at that, to be totally honest.
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korrents.com
Putting a device into the brain works in an hour, which makes it far more amenable to biology than drug discovery.Their words
It's like if I put electrodes in M1, you will probably be using a computer in an hour. Um and so it's just it's easier, it's more amenable to biology in many ways.
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korrents.com
Well-functioning systems succeed through continuous debugging rather than perfect initial design.Their words
When things work well, it's usually not because they were designed perfectly, but because they are constantly being debugged.
17 August
16 August
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Lovedrcmnd.app
Behave: The Biology of Humans at Our Best and WorstTheir words
What a great book! A lot of interesting research and anecdotal data. Changes your perception of human behavior quite a bit. There’s also an audio version narrated by the author. And a series of free Stanford lectures available on Youtube.
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Lovedrcmnd.app
The Selfish GeneTheir words
Having an interest in genetics and molecular biology, I was completely enchanted by the narrative.
7 August
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Their words
This is a little bit different than actually literally I vector centrality but it's very similar and so we call this technique IGEN reviews and I've become convinced that this is more or less the right way to do performance reviews.
6 August
3 August
29 July
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Their words
And I wonder sometimes if that is the reason people don't recognize the use of math in software engineering is because the math they do need is not the math they've been exposed to.
26 July
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korrents.com
The simple work gets automated away, but the hard sciences and the places where they intersect never will.Their words
I think the simple stuff is going to get automated away, but the hard problems, the hard sciences, um physics, chemistry, biology, uh you know, computer science, uh computer engineering, systems thinking, uh you know, all and and particularly the domains that are intersecting, uh those hard problems will never go away.
24 July
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Likedtheir ownrcmnd.app
Claude Opus 5Their words
Opus 5 is a great model for coding, data analysis, design, biology, knowledge work.
21 July
From one piece Intelligence is not the main bottleneck 2 beliefs, in the piece's order there
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korrents.com
Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be.Their words
In biomedicine we have a problem called target herding: most companies chase the same biological targets because they are de-risked, which means we explore far less of the biological space than we could.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
The patent system then further disincentivizes companies from taking target risk, because it rewards novel chemical matter, not novel biology.
Intelligence is not the main bottleneckwritingruxandrabio.com
14 July
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Likedaffiliate linkrcmnd.app
Decisions: Studying and Supporting People Facing Hard ChoicesTheir words
His narrative of the development of decision-making research over the past half-century is rich with personal anecdotes, gentle humor, continuous learning, and profound humility about how prone we all are to misjudge and misunderstand risks.
9 July
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Lovedaffiliate linkrcmnd.app
A History of BiologyTheir words
The chapter on medieval Islam wasn't very deep, otherwise this is truly excellent, particularly when covering the very complicated 20th century. I don't have much more to say, because it is so good, except that I should try to get my brother to review it.
6 July
29 June
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Their words
In truth, rather rapid electrification projects, without decade-by-decade continuity, exist outside the UK and are often quite reasonable in their costs, as in Denmark, Israel, and especially India.
21 June
10 June
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korrents.com
Manufacturing and batch-release requirements, not biology, are what kill most promising cell and gene therapies.Their words
Excessive manufacturing requirements are a pervasive problem, especially in the field of cell and gene therapy and they are killing countless of promising medicines before they ever reach patients.
From one piece “Curing All Disease by next century is too conservative" - Mark Zuckerberg 2 beliefs, in the piece's order there
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korrents.com
Open-sourcing biology models is right in principle but has to be balanced against biosafety.Their words
In terms of science, I think it really makes sense and we're deeply committed to open source. Um, there are obviously interesting considerations on this that are important too because there's a lot of considerations around biosafety and things like that that we're going to need to balance and think through how to how to handle.
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korrents.com
Biology models are smaller than language models only because there is less data, not because biology is simpler.Their words
I think in a lot of ways the data is actually even more of a constraint and um because if you look at like the scale of these models compared to language models they're smaller but they're smaller because the amount of data is less
9 June
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Their words
a more common trait that's related in the entrepreneurial world is obsessive learning like constant learning because the disruptions that allow for the technology waves that allow for companies to be disruptive and take market share from an incumbent are all tied to something dynamic that's happening on the edge.
8 May
From one piece David Reich – Bronze Age shock, the Neanderthal puzzle, & the sudden spread of farming 2 beliefs, in the piece's order there
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Their words
So, the cognitive resources for doing this must have all been in place, but it's a very long fuse.
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Their words
But, what's not been successful is learning about uh biology and biological change. And one big reason for that has been that the sample sizes have been too small.
13 April
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Their words
Fifth, for IIT to fit with current successful theories in fundamental physics, a reformulation in terms of continuous fields would be needed.
7 April
From one piece Michael Nielsen – Why aliens will have a different tech stack than us 2 beliefs, in the piece's order there
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Their words
and in some sense Darwin's genius wasn't in having that idea. It was understanding just how central it was uh to to to biology.
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Their words
we've been gifted uh just this incredible variety of machines which we don't understand really at all and we just have to go and sort of try and understand them on a you know, one-by-one basis.
23 March
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Their words
I don't love the other methods, which is continuous improvement. The problem with continuous improvement, it… First of all, you should engineer something from first principles at the speed, you know, with speed of light thinking. Limit it only by physical limits, and physics limits. And after that, of course you would improve it over time.
28 February
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Their words
Trials serve two distinct functions: validation — confirming whether a drug works and is safe — and learning, or generating biological data to refine our understanding of a disease, a compound, and the relationship between the two.
29 January
From one piece How Until is Engineering Away Time in Organ Transplants | Laura Deming 3 beliefs, in the piece's order there
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korrents.com
Temperature is a rare conceptual lever that lets you use physics to reason usefully about a biological problem.Their words
Basically what that gives you is like you can apply a lot of theoretical sort of um a lot of theoretical toolkit used in physics to model parts of this question in ways that are actually useful. And it is just not true that you can use like equations from physics to think usefully about almost any other problem in biology.
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Their words
you can make your life easier on the biology front by building better engineering tooling and the fact that that's possible is a huge deal. Like that is that is not true for most problems in biology and it gives you a lot of leverage on the problem.
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Their words
and I think most people experience it as like flat triangles and squares in a biology textbook where it's like you know there's an arrow between like this triangle and this triangle is just like doesn't make any conceptual sense and is like confusing and annoying
11 January
7 January
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Lovedaffiliate linkrcmnd.app
Continuous Discovery HabitsTheir words
Teresa Torres is the best in the business at helping teams build products and services that their customers want. Here she shares her techniques for transforming your process into one of continuous discovery and learning.
23 November 2025
5 October 2025
27 September 2025
19 August 2025
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Their words
I'm now fairly pessimistic about ambitious interpretability (i.e. complete reverse-engineering), and I'm excited about model biology (studying qualitative high-level properties of models) and applied interpretability (rigorously doing useful things with interp).
2 August 2025
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Their words
Some models could be used both for good and ill, yes. Diffusion models in particular could be used by bad actors to hallucinate toxins or other harmful proteins.
AI could help lead to an Alzheimer's cureblog.jacobtrefethen.com
22 July 2025
1 July 2025
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Their words
Even if late 30s eventually find love, the reproductive window is much smaller. Cash incentives can’t trump biology.
1 October 2024
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korrents.com
Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years.Their words
To summarize the above, my basic prediction is that AI-enabled biology and medicine will allow us to compress the progress that human biologists would have achieved over the next 50-100 years into 5-10 years.
19 September 2024
From one piece AI and Biology 3 beliefs, in the piece's order there
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Their words
So for these reasons, I (unfortunately) do not expect any big AI-driven breakthroughs in biological understanding any time soon.
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Their words
Most proteins are essentially unannotated, with their functions completely or mostly unknown.
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korrents.com
Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it.Their words
The "unknown unknown" problem makes hash (in retrospect) of many attempts at biological theorizing and modeling, and I think that this problem will still accrue to ML models until we know an awful lot more.
8 May 2024
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Their words
Our experiment demonstrates that the immense potential benefits of biotechnology are profoundly vulnerable to misuse.
5 May 2024
22 April 2024
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Their words
What a large language model is trying to do is to predict text. That’s what it does. And it is leveraging the fact that we human beings for very good evolutionary biology reasons, attribute intentionality and intelligence and agency to things that act like human beings.
25 March 2024
23 December 2023
From one piece The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it 2 beliefs, in the piece's order there
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Their words
Biology is unpredictable, especially when the immune system is involved, and there is no guarantee that a drug that appears safe in animals will be safe in humans.
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Their words
The most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make.
3 December 2023
20 November 2023
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Lovedrcmnd.app
The Song of the CellTheir words
If I had been able to read The Song of the Cell by Siddhartha Mukherjee in school, I might have fallen in love with biology a lot earlier.
1 September 2023
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Their words
What we don't want to happen with AGI, we want to happen with synthetic biology. What we don't want to happen online and software with language, we want for it to happen with bio-based materials.
16 August 2023
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Their words
Physics, chemistry and biology can point out problems, but we need history, economics and philosophy to solve them.
7 September 2022
From one piece Nick Lane: Origin of Life, Evolution, Aliens, Biology, and Consciousness | Lex Fridman Podcast #318 3 beliefs, in the piece's order there
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korrents.com
The Cambrian explosion is no longer much of a mystery; the big mystery left in biology is consciousness.Their words
I don’t think there’s a big mystery. There’s lots of details that need to be filled in. The big mystery in biology is consciousness.
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korrents.com
The primordial soup is a miracle story: life needs a continuous flow of reaction, and a soup can never provide one.Their words
So, how did they do that? You may as well say that a miracle happened. I don’t believe in soup. I think what we have in a vent is a continuous conversion, a continuous growth, a continuous reaction, a continuous converting a flow of molecules into more of yourself, you might say, even if it’s a small bit.
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Their words
And frankly biologists, most biologists are still very reluctant to even get themselves tangled up in questions like electrical fields influencing development. It seems like mumbo jumbo to a lot of biologists and it should not be because this is the 21st century biology.
24 August 2022
6 August 2022
15 July 2022
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Their words
In order to move this army or sustain it in place it is thus necessary to ensure a massive and relatively continuous supply of food to the army. Failure to do that will result in the army falling apart long before it comes anywhere close to the enemy.
1 January 2022
6 October 2021
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Their words
Like nuclear physics, with its potential for global catastrophe when put to destructive ends, the proliferation of pandemic biology ought to be considered a matter of international security.
18 January 2021
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Their words
Just because we use a different branch of math doesn't mean we're not doing engineering.
28 October 2020
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Likedaffiliate linkrcmnd.app
Biomimicry: Innovation InspiredTheir words
Who are the best engineers and designers in the world? Nature. This book is an interesting, science-heavy look at some really interesting properties in nature we could use to learn from as we try to design new technology. Benyus takes us across the spectrum from photosynthesis, to agriculture, to spiders. If you want to geek out on a little biology while applying it to technology this is a good read.
11 June 2020
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Likedrcmnd.app
Molecular Biology of the CellTheir words
undergoing some of these experiments was incredibly fun and a great excuse to study a number of textbooks on biochemistry (I liked "Molecular Biology of the Cell"), biology (I liked Campbell's Biology), human nutrition (I liked "Advanced Nutrition and Human Metabolism"), etc.
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Likedrcmnd.app
Campbell's BiologyTheir words
undergoing some of these experiments was incredibly fun and a great excuse to study a number of textbooks on biochemistry (I liked "Molecular Biology of the Cell"), biology (I liked Campbell's Biology), human nutrition (I liked "Advanced Nutrition and Human Metabolism"), etc.
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Likedrcmnd.app
Advanced Nutrition and Human MetabolismTheir words
undergoing some of these experiments was incredibly fun and a great excuse to study a number of textbooks on biochemistry (I liked "Molecular Biology of the Cell"), biology (I liked Campbell's Biology), human nutrition (I liked "Advanced Nutrition and Human Metabolism"), etc.
5 June 2020
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Likedrcmnd.app
suckless toolsTheir words
Suckless offers an alternative to this continuous cycle of bloat and meaningless redesign. Suckless tools aim to keep things simple, minimal, usable and hackable by default.
15 August 2019
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korrents.com
Scientific progress in biology is not slowing down.Their words
My (contrarian, I guess) intuition is that scientific progress in biology is not slowing down.
17 June 2018
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korrents.com
A team should grow in bursts followed by periods of consolidation, because continuous hiring never lets it gel.Their words
Adding new folks to a team disrupts that team’s gelling process, so I’ve found it much easier to have rapid growth periods for any given team followed by consolidation/gelling periods where the team gels.
22 December 2017
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