Laura Deming
Co-founder and CEO of Until, a reversible-cryopreservation company, and previously the founder of the Longevity Fund.
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Beliefs
Korrents What they believe 15 beliefs — each backed by an exact quote.
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Aging is neglected not for technical reasons but because it is not yet socially classified as a disease.
I think longevity and aging kind of occupy this weird realm where because they're not like explicitly diseases in a way that's fully socially recognized yet they're not seen as valid to work on but like that's not really for I think technical reasons on some level it's more for like classification reasons
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
The areas worth working on are the ones with a social blind spot around them.
I think longevity is interesting because it feels like an area where there's a social blind spot around something and I find those very interesting.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Medicine needs an ambulance of the future: a way to pause a dying patient's biological time until the cure for their disease arrives.
But right now like there's no way to press pause on their biological time. So like what if you had an ambulance of the future, right? Like what if you could take someone who is on their deathbed and um you know find some way to you know just sort of hibernate them basically until um the sort of critical cure for their disease comes online.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
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What will limit medical hibernation is not the technology but the social cost -- you cannot take the people around you with you.
but I think that the thing that a lot of people will face is just like this question of like is it worth you know traveling so far to give up my current social context and that will put a limit on like how much people want to use this for
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Cryopreservation is tractable because ice formation is a probabilistic process you can steer, not a threshold that flips.
but ice sort of forms through a process of random nucleation and then extension. And this is cool because you can uh modulate the like sort of nucleation the rate of nucleation and extension to then modulate the probability of ice formation.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
We already reversibly cryopreserve whole human bodies, at the few-hundred-cell stage, so the open question is scale and not possibility.
And so that's the last thing which was very surprising to me which is that like we already reversibly cry preserve tissue including human tissue including whole body human tissue at that very very small like you know in a couple hundred cells stage
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
In cryopreservation you can buy down biological difficulty with better engineering, which is not true of most problems in biology.
you can make your life easier on the biology front by building better engineering tooling and the fact that that's possible is a huge deal. Like that is that is not true for most problems in biology and it gives you a lot of leverage on the problem.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Temperature is a rare conceptual lever that lets you use physics to reason usefully about a biological problem.
Basically what that gives you is like you can apply a lot of theoretical sort of um a lot of theoretical toolkit used in physics to model parts of this question in ways that are actually useful. And it is just not true that you can use like equations from physics to think usefully about almost any other problem in biology.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
The brain is the one real unknown standing between organ cryopreservation and reversible whole-body preservation.
the big unknown to get to whole body reversible is the brain. Um it's unclear like like the brain can withstand a lot of change and does withstand a lot of different types of damage or or change with age for example.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Transplant patients regularly lose organs that are already on their way to them, purely because of timing.
basically transplant patients today surprisingly frequently miss organs that are on route to them because there's a timing problem. Um, so like you know, organs expire um very quickly after they become available from a donor.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Organs are among the most precious resources there are, and the system still moves them by putting a surgeon on a chartered jet at the last minute.
And it's crazy because like they're the they're like one of the most precious resources we know of. And yet like people regularly charter private jets, you know, like like you're putting a surgeon on a private jet to go pick up an organ, get it back to the patient in time.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Organ matching happens at literally the last minute, so nobody has the time to find the best match.
And then I also think um you know right now for matching it's like everything's done at literally the last minute. It's like someone dies, an organ comes available and like you're just kind of calling around trying to find like what patient is available to get this organ and you don't have that much time to make the optimal match, right?
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
The cruelty of the transplant system is what it does to the patient: waiting for a life-changing surgery with no idea when it will be scheduled.
I think the thing that feels the most compelling for me is just like the experience of the transplant patient. It's really I think constricting. It's like you're waiting for a life-changing surgery and you have no idea when it will even be scheduled
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Whole-body preservation cannot be discussed rationally: people either love it uncritically or fear that taking it seriously will taint them.
people either like love it and they love it so much that they won't question it or it's like they're worried that thinking about that associating with it is a little bit too science fiction for kind of where it might be optimal for them to be focused.
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
Biology is taught as flat triangles and arrows in a textbook, a depiction of the molecular world that makes no conceptual sense.
and I think most people experience it as like flat triangles and squares in a biology textbook where it's like you know there's an arrow between like this triangle and this triangle is just like doesn't make any conceptual sense and is like confusing and annoying
How Until is Engineering Away Time in Organ Transplants | Laura Deming Said 29 Jan 2026
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