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Autoimmune therapies: an inspiration for anti-aging therapies?
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16 September
14 September
11 September
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Their words
Artificial intelligence has unleashed a torrent of cheating on campus and created chaos in the job application process, as both students and employers use large language models: the former, to write hundreds of AI-assisted applications; the latter, to screen those AI-written applications with AI-written filters, thus removing from the process of finding a first job those procedural frictions sometimes known as "people."
9 September
8 September
6 September
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Their words
The US military is being run by a group that apes the Russians and not the Ukrainians—when we have in front of us one of the best statements of command principles I have ever seen from the latter.
3 September
2 September
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Their words
If you suffer from amygdala hyperactivity that gives you one of the aforementioned psychiatric disorders, I think that not only should you be offered elective amygdalectomy, but your health insurance should be glad to pay for it (especially if done via ultramodern very safe radiosurgery) one time, rather than for a lifetime supply of more expensive, less effective talk therapies and medications.
Absurd Adventure And Amygdalectomy Advocacyastralcodexten.com
21 August
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Their words
The way to win at capitalism is to focus on what it actually does (make customers' lives better) rather than the socialist caricature of it (squeeze every penny out of them). The latter gets you 2x returns at best, whereas making new things for people can get you 10x.
17 August
29 July
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Their words
So, it's hard to tell how much of like the loss of the past few years was AI versus the end of like zero interest rate policy and like the post-COVID crash. And I think it's more the latter, but like again, LLMs are still getting better.
19 July
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Their words
I think there's a difference between being able to write lines of code in a particular language like Python or C++ and understanding how code, computer systems, products work. And I don't think the latter is going away.
15 July
12 July
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korrents.com
China's cultural and intellectual output to the world is far smaller than its economic weight.Their words
It surely does not “produce” one quarter of world culture or intellectual activity (if the latter is defined as influential books, of fiction and non-fiction, politics, history; films, plastic arts, music, theater etc.)
18 June
10 June
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korrents.com
Manufacturing and batch-release requirements, not biology, are what kill most promising cell and gene therapies.Their words
Excessive manufacturing requirements are a pervasive problem, especially in the field of cell and gene therapy and they are killing countless of promising medicines before they ever reach patients.
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Their words
rather than studying the specific diseases we think that by trying to understand inflammation more broadly that will make it so that other companies that can then use these tools can work on specific therapies.
12 May
15 April
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Their words
We have got to acknowledge that most of the advanc advances in AI came out of algorithm advances not just the raw hardware. Now if most advances came from algorithms and computer science and programming tell me that their army of AI researchers is not their fundamental advantage.
21 January
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Their words
Habits and not expensive, exotic therapies.
18 September 2025
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Their words
However, we are actually absolutely doing this. It's just the great works are kernels of operating systems, the browser, the um lots of the software platforms, the phones, the um the incredible advances in uh silicon lithography
9 September 2025
4 September 2025
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Their words
So, giant eyeballs, they can either see very well, they can see a very long way in daylight, or they can see very well at night. And my suspicion is it's the latter. I think they're probably primarily nocturnal when they get that size.
18 August 2025
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Their words
I don't think all parts of the economy can absorb intelligence equally. So let's just say we develop fairly generalized super intelligence. I always use the analogy like you can invent a lot of drugs, but if clinical trials still take a long time, you're not necessarily going to get new therapies rapidly.
9 August 2025
2 August 2025
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Their words
Going all in on AI is not the highest return-on-investment strategy if you care about human flourishing, even if AI might lead to rapid scientific advances.
AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com
9 February 2025
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korrents.com
People will find new kinds of useful work as AI advances, though it will not resemble the jobs of today.Their words
We will find new things to do, new ways to be useful to each other, and new ways to compete, but they may not look very much like the jobs of today.
30 December 2024
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Likedrcmnd.app
Principles of the SPIN Model CheckerTheir words
This book gave me both insight and a deeper curiosity about the subject. This book introduces the SPIN model checker and exposes the reader to the nuances of verifying programs using SPIN. A nice feature of the book is how it explains concepts using thoughtfully developed, freely available tools (such as jSpin) that the author created for pedagogical purposes. It's a demanding book, but the content was interesting. The book presents details about concurrency, temporal logic, non-determinism, advanced SPIN topics, and even case studies. I've already written a few blog posts about the topics I explored while reading this book, and I plan to write more. Overall, it's a good book. I'm sure I'll revisit the latter half again.
22 December 2024
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Their words
So, we could be fooled into thinking like, "Oh, technology's going to go on forever, we're always going to find new advances." As opposed to sometimes things just flatten out for a long time. So, you have to be careful about that bias that we have living in this time of great acceleration.
3 September 2024
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korrents.com
Technology has made markets less efficient at long horizons rather than more efficient.Their words
Above I dismissed the notion that technological advances should make the market more efficient in all but the short-term sense. Here, I argue it likely goes the other way at longer horizons. And, IMHO, this is the best of my three hypotheses.
9 June 2024
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Their words
My hot take is that JS has the lowest bar of entry to building and being productive (a good thing) but one of the highest bars of any language and stack to building high quality, stable, and reliable software. Very few devs have the expertise to pull off the latter
10 May 2024
22 April 2024
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Their words
I think that that story about the latter part is completely wrong, almost 180 degrees wrong. I think that Einstein understood quantum mechanics as well as anyone, at least up through the 1930s. I think that his philosophical objections to it are correct. He should actually have been taken much more seriously about that.
1 October 2023
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Their words
At the end of the day, scientism still seems better than “no scientism,” given that the latter would leave the field open for highly irresponsible and also ideological -- ideological in all directions – pieces of policy advice.
14 January 2023
3 November 2022
8 October 2022
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korrents.com
The three-year bet about whether AI image models could handle compositionality was won in three months.Their words, before
In fact, not only did they reach this level in three months, but probably they were at this level before the bet was even made
Their words now
I retract my claim to have won and will continue to see how AI progress advances over the next three years.
15 July 2021
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Their words
Despite these advances, contemporary physical and evolutionary-history-based approaches produce predictions that are far short of experimental accuracy in the majority of cases in which a close homologue has not been solved experimentally and this has limited their utility for many biological applications.
14 April 2021
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Their words
Clearly something other than the current type of healthcare advances will be needed to crack through the natural human lifespan ceiling-it'll take some deeper recoding of the human genome.
1 February 2021
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