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Epidemiologist; founded Your Local Epidemiologist in March 2020 to translate public-health science, and consults for organisations including the CDC.

• Our readingkorrents.com

  Reclassifying a vaccine out of official routine-recommendation status erodes practical access to it even without changing the recommendation itself.

  Their words

  Moving a vaccine out of that category adds significant implementation barriers that will erode access to vaccines.

  yourlocalepidemiologist.substack.com

Epidemiologist; founded Your Local Epidemiologist in March 2020 to translate public-health science, and consults for organisations including the CDC.

• Our readingkorrents.com

  Getting seasonal vaccines is among the most effective actions people can take to stay healthy through fall and winter.

  Their words

  Getting vaccines is one of the best things you can do this fall and winter to stay healthy and minimize disruption to school, work, and travel.

  Your guide to fall 2026 vaccinesyourlocalepidemiologist.substack.com

Physician and neuroscientist at the University of Washington; researches brain health, metabolism and athletic performance.

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  About half of all dementia is preventable, and most of that preventable half is Alzheimer's disease and vascular dementia.

  Their words

  we've gotten to a point now where it's generally accepted that potentially half of cases of dementia are preventable and I think the majority of that falls into those first two buckets Alzheimer's and vascular dementia

  youtube.com

Co-founder and chief executive of Meta Platforms, the company he started as Facebook in 2004.

From one piece “Curing All Disease by next century is too conservative" - Mark Zuckerberg 2 beliefs, in the piece's order there

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  The right unit of study is a system like inflammation rather than a named disease — understand the system and others can build the therapies.

  Their words

  rather than studying the specific diseases we think that by trying to understand inflammation more broadly that will make it so that other companies that can then use these tools can work on specific therapies.

  youtube.com

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  The point is not to cure diseases but to build the tools with which the whole scientific field cures them.

  Their words

  And again, I mean, the the theory isn't that we're going to cure the diseases. We're not. um it's that we want to help accelerate the pace of progress for the whole scientific field.

  youtube.com

Genomics researcher and writer on science, biotech and the culture of research.

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  How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly.

  Psychotherapy

  Their words

  Lastly, the duration of a clinical trial does not merely determine how fast an individual therapy reaches patients. It also shapes which diseases attract serious investment and which do not.

  writingruxandrabio.com

Co-founder and CEO of Until, a reversible-cryopreservation company, and previously the founder of the Longevity Fund.

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  Aging is neglected not for technical reasons but because it is not yet socially classified as a disease.

  Their words

  I think longevity and aging kind of occupy this weird realm where because they're not like explicitly diseases in a way that's fully socially recognized yet they're not seen as valid to work on but like that's not really for I think technical reasons on some level it's more for like classification reasons

  youtube.com

Founder of Telegram, and before it of VK.

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  We overuse pills: a painkiller mutes the signal without removing the cause, and the makers are not incentivised to remove it.

  Their words

  No, I'm not saying that you should never take pills. There are obviously some diseases that you can only fight with antibiotics, for example. So, I'm not suggesting we go back to the Middle Ages, but what I'm saying is we overuse pills.

  youtube.com

Runs global health R&D at Open Philanthropy; writes about the science and medicine that could exist and does not.

From one piece AI will not suddenly lead to an Alzheimer's cure 2 beliefs, in the piece's order there

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  Because research is concentrated in rich countries, both what we know and what gets made are skewed away from the diseases of poor ones.

  Their words

  Research predominance in rich countries leads to skewed knowledge and product availability.

  AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com

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  Some diseases are technologically solved and still spread, because the remaining bottleneck is trust rather than science.

  Their words

  Measles is technologically “solved”, but not everyone trusts the solutions or their messengers.

  AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com

Runs global health R&D at Open Philanthropy; writes about the science and medicine that could exist and does not.

From one piece A Quantitative Approach to Vaccine Funding 2 beliefs, in the piece's order there

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  Infectious diseases get far less industry R&D per death than non-communicable ones, because they mostly kill people in countries where a cure pays less.

  Their words

  Infectious diseases as a category receive vastly less R&D spending from industry than non-communicable diseases, per death they cause, because they disproportionately kill people in lower- and middle-income countries where the payoff for making a cure is less lucrative.

  A Quantitative Approach to Vaccine Fundingblog.jacobtrefethen.com

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  R&D spending varies more than tenfold across diseases for no good reason, which is where the best opportunities in science funding are.

  Their words

  Our punchline is that R&D spending varies by 10X+ across diseases for no good reason. I've been poking at that punchline for the last six or so years, from different directions, and I am confident it's true.

  A Quantitative Approach to Vaccine Fundingblog.jacobtrefethen.com

Archaeologist of the Maya and the ancient Americas; directs the Maya Exploration Center and presents the ArchaeoEd podcast.

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  Spain and Portugal are unfairly maligned by the Black Legend: it was the diseases that killed the Americas.

  America

  Their words

  I think that the Spanish and the Portuguese get unfairly maligned in what’s been called the Black Legend, that they just marched into America and murdered everyone. That’s not the fact. It was the diseases that murdered everyone.

  youtube.com

Researcher and science writer. Co-founder and editor at Works in Progress magazine, formerly a researcher at Our World in Data, and author of the Scientific Discovery newsletter on science, global health and medical innovation.

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  The long decline in mortality is not guaranteed to continue: new shocks and old unsolved diseases can reverse it.

  Their words

  None of these trends are a given.

  scientificdiscovery.dev

Writes about the biotech industry, drug development and forecasting — “I write to learn, mostly about biotech.”

• Our readingkorrents.com

  How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly.

  Their words

  Because patents have fixed term lengths, with small extensions to compensate for the year or so when the drug is under regulatory review, drug developers are incentivized to go after conditions where clinical trials can be completed quickly, all else being equal.

  atelfo.github.io

Essayist; writes Astral Codex Ten, previously Slate Star Codex.

• Our readingkorrents.com

  The people who can be moved by deaths from neglected tropical diseases are the same people who can be moved by pandemics and by AI risk, because both come from reasoning about importance rather than from the news.

  AI alignment

  Their words

  And I notice that the tiny handful of people capable of caring about 200,000 people dying of neglected tropical diseases are the same tiny handful of people capable of caring about the next pandemic, or superintelligence, or human extinction.

  In Continued Defense Of Effective Altruismastralcodexten.com

Co-founder, chairman and chief investment officer of Ritholtz Wealth Management. Hosts the Masters in Business podcast for Bloomberg and wrote How NOT to Invest.

• Recommendsaffiliate linkrcmnd.app

  Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform Industries

  Their words

  Safi Bahcall, Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform Industries: How does group behavior and the science of phase transitions manifest itself? The author, a physicist and entrepreneur, tries to show why some wild new ideas become game changers. I was skeptical, but when someone like Danny Kahneman claims “This book has everything: new ideas, bold insights, entertaining history and convincing analysis. Not to be missed by anyone who wants to understand how ideas change the world,” I pay attention.

  ritholtz.com

Investment researcher and engineer who runs Lyn Alden Investment Strategy, writing on macroeconomics, currency systems and equity analysis.

• Recommendsrcmnd.app

  the work of Dr. Sarah Ballantyne

  Their words

  If you suffer one of those diseases, in addition to talking to your doctor, I recommend the work of Dr. Sarah Ballantyne. She has a PhD in medical biophysics, and managed to cure four of her own severe autoimmune diseases with the autoimmune protocol.

  lynalden.com