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17 September
15 September
14 September
10 September
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5 September
From one piece The Coronary Artery Inflammation Controversy 2 beliefs, in the piece's order there
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Their words
The “inflammation hypothesis” is not a hypothesis.
The Coronary Artery Inflammation Controversyerictopol.substack.com
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Their words
We know that arteries with a calcium (CAC) score of zero can be highly inflamed, and that high CAC scores are not necessarily high-risk for cardiovascular events.
The Coronary Artery Inflammation Controversyerictopol.substack.com
1 September
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korrents.com
Curing disease is not worth it if the price is the permanent deprecation of most human beings' existence.Their words
As someone coming from a biology background, who considers “curing disease” as a very noble mission, I still believe that the vague promise of “curing disease” is fundamentally not worth it if it comes with a form of permanent deprecation of most humans’ existence.
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korrents.com
A federal health agency withholding local disease-death data signals it distrusts states' own reporting.Their words
So, withholding the data signals that CDC is choosing not to trust the states' account. This is an unprecedented move.
25 August
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korrents.com
Defunding public health surveillance systems allows foodborne disease outbreaks to go undetected.Their words
When the public health systems meant to catch and stop this stuff are cut (less funding, less staff, less historical knowledge, and less leadership), outbreaks can, and will, emerge between the cracks.
24 August
From one piece How to Improve Motivation & Overcome Procrastination | Dr. Masud Husain 3 beliefs, in the piece's order there
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Their words
Alzheimer's disease does not necessarily equal dementia. people can have Alzheimer's disease and not get dementia. So, we found this out from post-mortem studies. People have been followed as they age. Uh they've donated their brains and it turns out that perhaps 20 to 30% of these individuals who never had dementia have Alzheimer pathology.
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What we find is that those individuals who score highly on just self-reported questionnaires for motivation, if they score highly for apathy, they have twice the risk of developing Alzheimer's disease than people who don't.
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So it's a different way of framing why is there a reduction of action? Why is there bradicynesia, a slowing of movement in people with Parkinson's disease? That's really interesting. It doesn't just have to be about motor control. It could be the motivation to act just as we said with David, right?
3 August
1 August
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In other words, the absence of calcium is not the same as the absence of disease—it may simply mean the disease hasn’t reached the stage CAC is designed to detect.
29 July
25 July
20 July
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we've gotten to a point now where it's generally accepted that potentially half of cases of dementia are preventable and I think the majority of that falls into those first two buckets Alzheimer's and vascular dementia
13 July
From one piece How to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel 2 beliefs, in the piece's order there
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And I think, you know, most people when they talk about aging, they're so worried about dementia and, you know, Alzheimer's disease as a specific form, but balance is even more important, I think. And most people aren't even aware of their balance.
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and you found that these nuns, how they aged, some of them certainly when they passed away, their brains had these kind of hallmark signs of dementia, plaques and tangles, but behaviorally they were still high functioning. So, it's really interesting that the hardware shows what we see as dementia and specifically Alzheimer's disease, but their behavior uh was that of a fairly healthy cognitive person.
10 June
From one piece “Curing All Disease by next century is too conservative" - Mark Zuckerberg 3 beliefs, in the piece's order there
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korrents.com
Disease will never be finished, because the body is a dynamic system: fix one thing and the next appears.Their words
I mean, I'm optimistic it'll be sooner. I mean, I think that the thing that's complicated is that it's a dynamic system, right? So, if you fix something, there will obviously be future things that you need to work on.
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rather than studying the specific diseases we think that by trying to understand inflammation more broadly that will make it so that other companies that can then use these tools can work on specific therapies.
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korrents.com
Curing, preventing or managing all disease by the end of the century is now too conservative a goal.Their words
But still, I thought that by the end of the century was a stretch. Now, I think it's like uh too conservative.
1 May
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korrents.com
Preventing the underlying causes of public health fears works better than debunking them after they take hold.Their words
The only solution is preventing the disease, not treating the symptoms.
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Their words
I have a pet theory that removing the option for antibiotics forces farms to treat animals better, because bad conditions engender disease and without the quick fix of antibiotics that can get very expensive.
25 April
26 March
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Recommendsaffiliate linkrcmnd.app
Celiac Travel CardsTheir words
If you or someone you love has Celiac disease, these travel cards are a useful resource! (Use the code NOMADICMATT for 10% off!)
28 February
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Their words
Trials serve two distinct functions: validation — confirming whether a drug works and is safe — and learning, or generating biological data to refine our understanding of a disease, a compound, and the relationship between the two.
29 January
From one piece How Until is Engineering Away Time in Organ Transplants | Laura Deming 2 beliefs, in the piece's order there
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But right now like there's no way to press pause on their biological time. So like what if you had an ambulance of the future, right? Like what if you could take someone who is on their deathbed and um you know find some way to you know just sort of hibernate them basically until um the sort of critical cure for their disease comes online.
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korrents.com
Aging is neglected not for technical reasons but because it is not yet socially classified as a disease.Their words
I think longevity and aging kind of occupy this weird realm where because they're not like explicitly diseases in a way that's fully socially recognized yet they're not seen as valid to work on but like that's not really for I think technical reasons on some level it's more for like classification reasons
26 December 2025
24 December 2025
2 August 2025
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Those are why I do not believe that AI could end disease within 10 years on its own, nor that 50-100 years of medical progress could occur 5-10 years after powerful AI due to AI progress alone
AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com
20 May 2025
14 April 2025
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Cure the disease, not the symptoms. Reform taxes to tax consumption, not saving and investment. Stop funneling borrowed money to consumption.
21 January 2025
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African states formed where it was rational to do so, in places like the Ethiopian highlands where population density was high and the disease burden was relatively low.
19 January 2025
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korrents.com
If every growth initiative is an experiment, the team has a paralysing disease rather than a process.Their words
If every single one of your initiatives that you're doing on growth is an experiment, uh that's a problem.
22 June 2024
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In fact, even though growth in average infrastructure costs over time is documented, there is very little cross-national correlation between GDP per capita and per-km subway construction costs.
13 May 2024
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korrents.com
The drugs advertised as having AI-discovered targets are aimed at targets people already knew about.Their words
What you will see is that in almost every case, these targets were already known to be implicated in the disease under investigation.
23 December 2023
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Their words
The most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make.
30 October 2023
11 October 2023
1 October 2023
13 March 2023
20 October 2020
5 May 2020
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