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Economist at George Mason University, co-author of Marginal Revolution, host of Conversations with Tyler. Writes in short, dense claims about economics, culture and AI, and has moved position on AI in public more than once.

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  Cybersecurity-related risks warrant more pessimism than current market prices indicate.

  Their words

  Hardly the final word, and I am myself more pessimistic than those numbers indicate.

  Callum Williams on cybersecurity pricesmarginalrevolution.com

Cardiologist and founder of the Scripps Research Translational Institute; writes Ground Truths on biomedical research, and wrote Super Agers and Deep Medicine.

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  Inflammation's role in coronary artery disease is proven, not hypothetical; what is missing is a safe and potent way to reduce it.

  Their words

  The “inflammation hypothesis” is not a hypothesis.

  The Coronary Artery Inflammation Controversyerictopol.substack.com

Sequoia Professor of Computer Science at Stanford, co-director of the Stanford Institute for Human-Centered AI, and co-founder and CEO of World Labs.

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  Intelligence is not sitting still and interpreting what you see; it is closing the loop between seeing, experiencing and interacting.

  Their words

  I think for me, let's go back to the first principle of intelligence. Intelligence is not sitting there stuck and just seeing something or interpreting something when it comes to space and physical space, right? It's really this uh closing the loop between seeing and experiencing and interaction.

  youtube.com

Founder of Trilogy Software and principal of Alpha School, the private school network built around two hours a day of AI-delivered mastery learning.

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  The world has achieved universal access to school and nowhere near universal learning, and closing that second gap is the whole problem left in education.

  Their words

  We have universal access. What we are trying to do is bring universal learning. So there's a vast disparity in how much kids learn during that 12 years that while they may have access to it, learning is very different.

  youtube.com

Writer and author of All the Wrong Moves; his newsletter covers meditation, relationships and creativity, and he co-runs a perfume line.

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  The mind's planning and goal-setting function is only a small fraction of a person's overall intelligence.

  Their words

  The planning part of your mind, the one that generates ambitions and hypothetical situations, is a small part of your overall intelligence.

  Surrender as a non-stupid life strategysashachapin.substack.com

Chief executive of Intel since 2025, founder of the venture firm Walden International and chief executive of Cadence Design Systems for thirteen years.

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  Semiconductor infrastructure has not kept up with AI's growth, and closing that gap needs capacity built in unconventional ways.

  Their words

  He and I, we share the same view that semiconductor infrastructure actually is not catch up with the AI growth.

  youtube.com

Statistician and software engineer who writes R packages for reproducible research and publishing, including knitr, bookdown and blogdown.

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  Closing and deleting a question to enforce site rules harms the real person who needed help, not just violates policy.

  Their words

  The point is a user is looking for help, and a maintainer is willing to help and knows a solution. They are all real humans. You guys are hurting them by closing and deleting the question.

  Bye, Stack Overflowyihui.org

Author of The Lean Startup and Incorruptible, and founder of the Long-Term Stock Exchange, who advises companies on corporate governance and mission protection.

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  Every founder on standard documents has already signed a charter obliging them to sell their company to the buyer they would least want to have it.

  Their words

  did you know that according to the legal documents you yourself signed, your company's literal charter that you have right now, and this is not some hypothetical future thing, you've already put in motion, a rule that says you have a fiduciary duty to say yes in this situation.

  youtube.com

Writer and technology executive; blogs at anildash.com, was CEO of Glitch, and helped build Movable Type and ThinkUp.

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  Closing off interoperability is how a platform locks people in, and that lock-in is what lets the service be made worse without losing them.

  Their words

  Meanwhile, others like Spotify and Netflix leverage their dominant positions in the market to coerce creators to abandon open podcasts entirely, in favor of proprietary formats that require listeners to be on those platforms — locking in both creators and their audiences so they are stuck as they begin the enshittification process.

  Endgame for the Open Webanildash.com

American budget-travel writer who publishes as Nomadic Matt. Author of How to Travel the World on $50 a Day; runs nomadicmatt.com, a long-running site of destination guides, packing advice and gear recommendations.

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  Unbound Merino

  Their words

  I really love the material, they're comfortable, they hardly ever need a wash, and they last forever!

  nomadicmatt.com

Writer and academic, author of The Cult of Smart and How Elites Ate the Social Justice Movement; writes a daily newsletter on politics, education and culture.

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  Any teaching method that helps the weakest students also helps the strongest, so closing the gap between them is not something teaching can do.

  Their words

  Because some people are simply better at school than other people, any pedagogical strategy, practice, or method that improves the performance of the worst students will also improve the performance of the best students

  Education Doesn't Work 3.0freddiedeboer.substack.com

Programmer and streamer; was an engineer at Netflix, now teaches and argues about editors, Vim and how people learn to program.

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  Prompt injection is an extremely hard attack to defend against, and hardly anyone integrating AI is talking about it.

  Their words

  One thing that I don't think a lot of people are talking about as we integrate more and more AI is that prompt injection is an extremely hard thing to defend against because it's not really clear how you defend against it.

  youtube.com

Founder and chief analyst of SemiAnalysis; reports on semiconductor supply chains, AI datacentre economics and what the chip export controls actually do.

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  AMD's hardware is in many ways better than NVIDIA's and it does not matter, because the software gulf is too large and AMD has never resourced closing it.

  Their words

  And they're decent, their hardware is better in many ways than in NVIDIA's. The problem is their software is really bad and I think they're getting better, right? They're getting better, faster, but the gulf is so large and they don't spend enough resources on it or haven't historically, right?

  youtube.com

Astrobiologist and theoretical physicist at Arizona State University, working on assembly theory and the physics of life.

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  Treating the universe as deterministic is an artifact of how laws have been written down since Newton, not a fact about the world.

  Their words

  Physics hardly even acknowledges that the universe is random at its base. We like to think we live in a deterministic universe and everything’s deterministic. But I think that’s probably an artifact of the way that we’ve written down laws of physics since Newton invented modern physics and his conception of motion and gravity, which he formulated laws that had initial conditions and fixed dynamical laws.

  youtube.com

Research scientist at Meta in Berlin working on multilingual models and evaluation; led the multilingual team at Cohere and was a research scientist at Google DeepMind before that.

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  The performance gap between closed-source and open-weight language models is closing.

  Their words

  I'm excited about what this means for the open-source community and research, with the gap between closed-source and open-weight models closing and SOTA-level conversational models being more easily accessible.

  Command R+ruder.io

Writes about the biotech industry, drug development and forecasting — “I write to learn, mostly about biotech.”

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  Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.

  Their words

  The cost to discover and develop a drug today is orders of magnitude higher than in the 1950s. Despite this, the probability that a drug entering clinical trials will eventually reach the market has hardly improved in the intervening years.

  atelfo.github.io

Political scientist at the University of Chicago and the leading exponent of offensive realism; wrote The Tragedy of Great Power Politics.

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  Russia's refusal to accept NATO on its border is exactly what the United States demands for its own neighbourhood.

  RussiaAmerica

  Their words

  Well, what's good for the goose is good for the gander. And if we don't like great powers coming into our neighborhood, it's hardly surprising that the Russians did not want NATO on their doorstep.

  youtube.com

Historian of invention; writes Age of Invention on where the Industrial Revolution actually came from.

From one piece Age of Invention: Does History have a Replication Crisis? 2 beliefs, in the piece's order there

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  History has a reproducibility problem worse than science’s replication crisis, because hardly anyone ever goes back to the sources to check what a historian claimed they say.

  Their words

  But I’ve become increasingly worried that science’s replication crises might pale in comparison to what happens all the time in history, which is not just a replication crisis but a reproducibility crisis.

  ageofinvention.xyz

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  The field of history runs on a trust it has not earned: almost nobody ever checks a citation, so an error can propagate unchallenged indefinitely.

  Their words

  But it’s hard to trust when you are exposed to one of the most frightening of revelations: that hardly anyone ever bothers to check.

  ageofinvention.xyz

Science fiction novelist, journalist and technology activist; writes the daily blog and newsletter Pluralistic, and coined the term enshittification.

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  Closing off interoperability is how a platform locks people in, and that lock-in is what lets the service be made worse without losing them.

  Their words

  The temptation to enshittify is magnified by the blocks on interoperability: when Twitter bans interoperable clients, nerfs its APIs, and periodically terrorizes its users by suspending them for including their Mastodon handles in their bios, it makes it harder to leave Twitter, and thus increases the amount of enshittification users can be force-fed without risking their departure.

  Tiktok's enshittificationpluralistic.net

Game designer; chief creative officer at Spry Fox (Triple Town, Realm of the Mad God) and author of the Lost Garden design blog.

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  Closing off the ways people can hurt each other in a shared space also closes off the ways they can befriend each other.

  Their words

  By eliminating the bad aspects of humans interacting, you often also remove many of the good parts.

  lostgarden.com

Ancient and military historian; writes A Collection of Unmitigated Pedantry, long series checking what history actually says against how popular culture tells it.

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  A pre-modern countryside produces an enormous amount of food and almost no extractable surplus, which is the hard limit on everything the state above it can do.

  Their words

  There is a ton of food in this countryside (nearly everyone is producing it) but hardly any surplus.

  acoup.blog