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19 September
18 September
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Their words
The moment when you realize that you thought drugs were powerful and meditation was mild, but you now realize the opposite is true.
Average moments of a long-term meditatorsashachapin.substack.com
17 September
16 September
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it'd so easy to compete with them because they're usually not even trying to do more
15 September
14 September
11 September
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All of these are things that power users IMMEDIATELY notice and get annoyed. But there's no good way to report them, and the eng teams clearly are flying blind, patting themselves on the back how everything is up velocity-wise... but product quality got degraded! And they don't even know
10 September
7 September
3 September
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Likedaffiliate linkrcmnd.app
WiseTheir words
Wise - great service for transferring money between currencies at very low rates (Affiliate link - get £15 off with first transfer)
2 September
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Their words
I think people really underestimate how many people are on gear (TRT, Tren, HGH etc) and are not natural
1 September
27 August
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korrents.com
Killing suspected drug smugglers at sea without trial is murder, because smuggling is not a capital offence.Their words
Even if it turned out that they were drug smugglers, as claimed, and even if it turned out that they were bringing drugs to the United States, a dubious proposition, the penalty for smuggling drugs is not summary execution.
25 August
20 August
From one piece From Restoring Sight to Reimagining the Brain, with Max Hodak 2 beliefs, in the piece's order there
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korrents.com
Humanity is not good enough at molecular biology to make drugs that restore vision or hearing or stop Parkinson's.Their words
People have spent huge amounts of time and money looking for drugs to restore vision or to restore hearing or to stop Parkinson's or to to help paralyzed people move again. Understanding the like the biology and the molecular detail required to make a drug has been very difficult. Humanity just isn't that good at that, to be totally honest.
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Yeah, I mean I think BCI is a category kind of like how pharma is a category. I think sometimes you I I'll talk to VCs and like, "Oh, we have a BCI bet." I'm like, "Do you have a drug bet? You made one bet on a drugs? Like that's that's how you think about the category?"
15 August
12 August
11 August
10 August
7 August
6 August
29 July
21 July
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Their words
Take Eroom’s Law: the number of new drugs approved per dollar of R&D has fallen for decades, even as our scientific tools have grown vastly more powerful, the exact opposite of what the existence of more raw capability would predict.
Intelligence is not the main bottleneckwritingruxandrabio.com
4 July
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Their words
That’s a lesson we could all learn about our approach to supplements and even drugs: not to fall for hazy promises that a single molecule will deliver vaguely-defined benefits for all aging persons, but to demand rigorous evidence for well-defined benefits for well-defined problems in well-defined populations.
Metformin and cancer: active surveillance neededpeterattiamd.com
29 June
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Likedrcmnd.app
gemma4:26b-a4b-it-q4_K_MTheir words
The absolute gonzo gemma4:26b-a4b-it-q4_K_M performance-wise. What is going on here that is making it such an extraordinary outlier?
28 June
27 June
10 June
24 May
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Wise people don't suppress emotion-they find constructive ways to express it.
3 May
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korrents.com
AI coding assistants are leveling the skill gap between software developers who can afford to use them.Their words
Skill-wise, most software developers, as long as they are willing/able to pay for AI assistants, are on the same page now.
28 February
From one piece A response to Dario Amodei on AI & clinical trials 3 beliefs, in the piece's order there
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Even if AI can help design more effective drugs, timelines will not compress until we solve the operational and regulatory bottlenecks of trials.
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The current success rate for a drug entering clinical trials is only about ten percent, meaning 90 percent of all drugs fail.
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Lastly, the duration of a clinical trial does not merely determine how fast an individual therapy reaches patients. It also shapes which diseases attract serious investment and which do not.
28 December 2025
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Recommendstheir ownrcmnd.app
Hard DrugsTheir words
And if you prefer podcasts, may I suggest Hard Drugs
19 September 2025
From one piece Norman Ohler: Hitler, Nazis, Drugs, WW2, Blitzkrieg, LSD, MKUltra & CIA | Lex Fridman Podcast #481 3 beliefs, in the piece's order there
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Their words
That was the victorious idea. So it's not the drugs. Actually, that idea to go through the Ardennes Mountains, if you think monocausal, you would say that's the reason. That idea was genius, and Hitler immediately understood it, because before, the plan was to attack in the north of Belgium, which is the same as World War I.
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So the Navy hired the shoe runners unit from the SS, paid them money, and then gave them drugs, different kinds of drug combinations, methamphetamine combined with cocaine and chewing gum and all kinds of things. So this is a big thing, you know. And there are documents to it.
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And he said this is actually the missing link that historians did not have, especially to explain Hitler's degeneration as a leader. He made very good decisions, good in meaning militarily effective decisions in the beginning of the war, and very bad decisions for the German war effort towards the end. And you can link that to drugs.
18 August 2025
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I don't think all parts of the economy can absorb intelligence equally. So let's just say we develop fairly generalized super intelligence. I always use the analogy like you can invent a lot of drugs, but if clinical trials still take a long time, you're not necessarily going to get new therapies rapidly.
9 August 2025
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Likedrcmnd.app
Blitzed: Drugs in Nazi GermanyTheir words
However, after reading a few pages my original inhibitions were overturned and I bought the book.
2 August 2025
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Their words
The design of the initial molecules to test is pretty magic-feeling, and is happening already – but the arrival of new drugs prescribed by your doctor will not be magical and sudden.
AI could help lead to an Alzheimer's cureblog.jacobtrefethen.com
11 June 2025
28 May 2025
From one piece What Was The War on Drugs? Part V 3 beliefs, in the piece's order there
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korrents.com
Drug enforcement cut casual use and barely touched heavy users, who account for most of the drugs consumed.Their words
But by the available evidence, the War on Drugs was far less successful at reducing use among the “hard core” of users, mostly meaning people addicted to their drug of choice.
What Was The War on Drugs? Part Vthecausalfallacy.substack.com
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Drug offenders never accounted for a particularly large fraction of the U.S. prison population, peaking at about 22 percent of state prisoners in 1990.
What Was The War on Drugs? Part Vthecausalfallacy.substack.com
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korrents.com
After two decades of the war on drugs, drugs were cheaper and more potent than when it began.Their words
After two decades of the War on Drugs, in other words, drugs were much cheaper and more potent than they were when the War on Drugs began.
What Was The War on Drugs? Part Vthecausalfallacy.substack.com
20 December 2024
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I don’t think many in the West have yet fully internalized a mental model of China as a source of genuine innovation.
30 September 2024
From one piece Ed Barnhart: Maya, Aztec, Inca, and Lost Civilizations of South America | Lex Fridman Podcast #446 2 beliefs, in the piece's order there
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In fact, strangely, the majority of plants that are actually psychotropic, not just mood altering, are from here in the Americas. There are very few drugs that will make you hallucinate outside of the Americas.
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korrents.com
Graham Hancock's research is good; his conclusion that one lost civilization seeded all the others is not.Their words
I do not believe Graham’s idea that a single, now lost ancient civilization seeded the rest of them. I just don’t see that on a number of levels, artifact wise, technology wise, art, historical analysis.
13 May 2024
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korrents.com
The drugs advertised as having AI-discovered targets are aimed at targets people already knew about.Their words
What you will see is that in almost every case, these targets were already known to be implicated in the disease under investigation.
22 March 2024
From one piece Annie Jacobsen: Nuclear War, CIA, KGB, Aliens, Area 51, Roswell & Secrecy | Lex Fridman Podcast #420 2 beliefs, in the piece's order there
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Because why on earth there would be two candidates, one of whom has cognitive problems and the other of whom has judgment problems? These are the two biggest issues with the nuclear launch, judgment and cognition. And so where’s the young-ish, thoughtful, forward looking, wise, dedicated civil servant running for president? I know that sounds fantastical, but I wish it weren’t.
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So you don’t have wise decision makers. Long gone are the days where we had presidents who had advisors on both sides of the aisle. That’s really important, because you want to have differing opinions. But as things become more viperous, both here in the United States and in nuclear armed nations, all bets are off at whether your advisors are going to give you good advice.
23 December 2023
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Because patents have fixed term lengths, with small extensions to compensate for the year or so when the drug is under regulatory review, drug developers are incentivized to go after conditions where clinical trials can be completed quickly, all else being equal.
9 November 2023
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I think it would be wise for us to have at least an objective third party who can be like a referee that can go in and understand what the various leading players are doing with AI, and even if there’s no enforcement ability, they can at least voice concerns publicly.
30 October 2023
9 July 2023
25 May 2023
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Their words
There are no existing AI/ML systems that mitigate clinical failure risks due to target choice or toxicology.
14 March 2023
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korrents.com
The beliefs worth changing are the defended ones, so changing a mind is a siege rather than a conversation.Their words
To impart wisdom, then, is to lay siege to someone’s mind-castle, because the only things worth being wise about are hidden behind the walls.
You can't reach the brain through the earsexperimental-history.com
16 June 2020
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