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Patrick Collison x.com
Excellent and important piece on clinical trials from @RuxandraTeslo:
The the words it uses that this site has seen least often elsewhere. Posts are matched on those words alone — nothing here is a summary of this one.
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19 September
18 September
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This Is Going To Hurt is, read with a clinical eye, a textbook case study of moral injury and post-traumatic stress in a competent doctor, narrated by the patient himself, with the diagnosis hidden in plain sight.
16 September
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I run an advocacy group that works on reforming clinical trials and the FDA, and I think cheap superforecasting could revolutionize our field.
AI Superforecasting Should Transform The FDAastralcodexten.com
14 September
5 September
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We can’t count on surrogate blood markers to guide the results of cardiovascular clinical outcome trials.
The Coronary Artery Inflammation Controversyerictopol.substack.com
3 September
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Recommendstheir ownrcmnd.app
Therapeutic Yoga for Trauma Recovery: A Clinical Summit for Mind-Body HealingTheir words
There’s still time to join me for Therapeutic Yoga for Trauma Recovery: A Clinical Summit for Mind-Body Healing!
28 August
25 August
24 August
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if you do for some reason generalize maladaptively to thinking this didn't work and I tried this, this didn't work, and I tried this and I'm really bad at this. That can lead not only to loss of motivation, but what we might call clinical depression.
7 August
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I think one of the things that makes science the company very special is that it has both of those cultures and is able to integrate them and we're able to simultaneously do some really cool research that I think is really at the edge of the Overton window while simultaneously running clinical trials in six countries now with an approved medical device in Europe and clinical trial results in the New England Journal of Medicine.
31 July
25 July
21 July
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I told him what I believe: that in the age of AI, medicine will be bottlenecked more than ever by regulation and the grind of clinical trials, and that billions poured into faster pre-clinical research won’t touch that problem, unsexy as it is.
Intelligence is not the main bottleneckwritingruxandrabio.com
18 April
23 March
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2 March
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The central clinical proposition of polyvagal theory-that autonomic state functions as an organizing platform shaping perception, emotion, and relational behavior-was not empirically disproven in the critique.
28 February
From one piece A response to Dario Amodei on AI & clinical trials 4 beliefs, in the piece's order there
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Even if AI can help design more effective drugs, timelines will not compress until we solve the operational and regulatory bottlenecks of trials.
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The current success rate for a drug entering clinical trials is only about ten percent, meaning 90 percent of all drugs fail.
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Lastly, the duration of a clinical trial does not merely determine how fast an individual therapy reaches patients. It also shapes which diseases attract serious investment and which do not.
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Trials serve two distinct functions: validation — confirming whether a drug works and is safe — and learning, or generating biological data to refine our understanding of a disease, a compound, and the relationship between the two.
18 September 2025
22 August 2025
From one piece The Rumpelstiltskin effect: therapeutic repercussions of clinical diagnosis (with 1 co-authors) 2 beliefs, in the piece's order there
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korrents.com
Diagnoses that have therapeutic effects are medical interventions and should be treated and researched as such.Their words
If a clinical diagnosis can have a therapeutic effect, then, at least in some instances, diagnoses are medical interventions in themselves and ought to be treated and researched as such, with an eye to both positive effects and potential iatrogenic harms.
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korrents.com
Clinical diagnosis can have a therapeutic effect independent of any other intervention.Their words
Their experiences highlight a striking, neglected and unchristened medical phenomenon: The therapeutic effect of a clinical diagnosis, independent of any other intervention, where clinical diagnosis refers to situating the person's experiences into a clinical category by a clinician or the patient.
18 August 2025
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I don't think all parts of the economy can absorb intelligence equally. So let's just say we develop fairly generalized super intelligence. I always use the analogy like you can invent a lot of drugs, but if clinical trials still take a long time, you're not necessarily going to get new therapies rapidly.
2 August 2025
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Those are why I do not believe that AI could end disease within 10 years on its own, nor that 50-100 years of medical progress could occur 5-10 years after powerful AI due to AI progress alone
AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com
20 February 2025
20 December 2024
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korrents.com
China now starts about a quarter of the world's new clinical trials, more than Europe does.Their words
Chinese companies are now responsible for about a quarter of new trial starts — more than Europe.
1 December 2024
21 May 2024
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It's time for the field to stop attributing benefits to clinical experience. Beyond the obvious ethical concerns, doing so actually prevents us from improving our effectiveness!
10 May 2024
23 December 2023
From one piece The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it 4 beliefs, in the piece's order there
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The cost to discover and develop a drug today is orders of magnitude higher than in the 1950s. Despite this, the probability that a drug entering clinical trials will eventually reach the market has hardly improved in the intervening years.
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Because patents have fixed term lengths, with small extensions to compensate for the year or so when the drug is under regulatory review, drug developers are incentivized to go after conditions where clinical trials can be completed quickly, all else being equal.
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The most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make.
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korrents.com
Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour.Their words
Clinical trials are expensive because they are complex, bureaucratic, and reliant on highly skilled labour.
30 October 2023
25 May 2023
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There are no existing AI/ML systems that mitigate clinical failure risks due to target choice or toxicology.
16 June 2020
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