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17 September
Entrepreneur and founder of Blueprint. Publishes a detailed, freely available longevity protocol documenting the food, supplements, devices and measurements he uses on himself.
We were surprised yesterday to learn that Kate was being asked to fill her vagina with ultrasound gel. The MRI was to characterize her endometriosis. A disease where endometrial tissue develops outside the uterus and grows. It's a gnarly and painful disease with serious health complications. It affects 1 in 10 women and currently takes on average 6.6 years to diagnose. We hustled and diagnosed Kate's endometriosis in 42 days via four speciality different tests (blood, MRI, salvia, transvaginal ultrasound). The fastest and most comprehensive ever, I think. We are doing this MRI because we have… Quoting @_katetolo I had to fill my vagina with ultrasound gel yesterday for an MRI... I had no idea this was a protocol for measuring endometriosis! how cool It's a technique called vaginal opacification... the vagina is normally a collapsed space, and on an MRI, collapsed walls are hard to tell apart from the tissu… Related
13 September
Entrepreneur and founder of Blueprint. Publishes a detailed, freely available longevity protocol documenting the food, supplements, devices and measurements he uses on himself.
I frequently lay on top of Kate with all of my bodyweight. The deep pressure calms her nervous system, quiets racing thoughts, and releases oxytocin which lowers cortisol. We call it GLP-Bryan. Related
12 September
Entrepreneur and founder of Blueprint. Publishes a detailed, freely available longevity protocol documenting the food, supplements, devices and measurements he uses on himself.
Kate and I have a rule: no fighting after 5 pm. Related
9 September
Technology writer of Spyglass, a newsletter about technology and media. Previously a reporter at TechCrunch and an investor at GV.
1 hour 18 minutes. Flew by. Good showing by Ternus. Quick honest reaction is: better than Cook at these keynotes, but lacks the off-the-cuff nature and energy of Jobs. It's early. But also we NEED to go back to live. iPhone Duo demos would have been awesome live. #AppleEvent energy Related
8 September
Designer and technologist; author of The Laws of Simplicity; former president of the Rhode Island School of Design; formerly at the MIT Media Lab.
AUTODESIGNING PPTX: While trying to understand the new @github HydraFusion Project https://t.co/B03qBEWQQK I made my seventh attempt at a bespoke, and on-brand, PPTX deck tool for my brother @mariorod1 to cook with as a custom GitHub Copilot Canvas. It's getting an awfully lot easier to work within Swiss typographic grids in "creative" ways that make the literal roll of the dice satisfyingly fast without making so many LLM calls. Next, I'm looking forward to adding all the interesting GEPA and GRPO stuff that will enable compounding learning capabilities. —JM --- Cozy AI Recipe: - I pointed G… youtu.be
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7 September
Author of Quiet: The Power of Introverts and of Bittersweet; writes The Quiet Life newsletter.
4 September
Writer and programmer; co-founder of the software studio Postlight and author of the Bloomberg Businessweek essay What Is Code?
If you’re a Flatbush-area mutual aid type, this self-organizing distro happens every Friday at 5PM across the street from Kings Theatre. If you want to help show up and hand out food or clothes, or just donate via Venmo. Or cook! Related
3 September
Indian value investor who taught Behavioural Finance and Business Valuation as an adjunct professor at MDI Gurgaon. He writes the Fundoo Professor blog about investing, moats and mental models.
Apple's market cap was about $351–360 billion when Steve Jobs died. On September 1, 2026, Tim Cook's last day as CEO, it was $4.75 trillion. When Ballmer handed over to Satya Nadella in Feb 2014, Microsoft market cap was about $315B. It’s $3.7 trillion now. Similar outcome with Sam Walton and Wal-Mart. It went the other way with GE and Jack Welch. So, it cuts both ways, and I think the deciding factor is whether the underlying business quality, moat, and capital-allocation discipline survive the transition intact. Quoting @menakadoshi The events at HDFC Bank confirm two of my worst suspicions. One, celebrity founders and CEOs often leave behind a leadership vacuum. As the adage goes, nothing grows under a banyan tree. India is witnessing that more frequently as part of the great handover from post-liberalization leaders to the n… Related
31 August
Technology writer and podcaster; former Macworld editor-in-chief, writes Six Colors and hosts podcasts on Relay FM and The Incomparable.
New Upgrade: It's time for another Apple event draft! But before we predict what Apple will introduce next week, we need to send off the Tim Cook Era and discuss a somewhat surprising announcement of new chips and new Macs! relay.fm
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On this day of all days, here’s my earliest photo of Tim Cook, and of course @Pschiller is there too! Plus some other guy. This is October 2008, in which Tim presented the new Mac releases! Related
29 August
Author of Quiet: The Power of Introverts and of Bittersweet; writes The Quiet Life newsletter.
28 August
Author of Quiet: The Power of Introverts and of Bittersweet; writes The Quiet Life newsletter.
21 August
Entrepreneur and founder of Blueprint. Publishes a detailed, freely available longevity protocol documenting the food, supplements, devices and measurements he uses on himself.
Short kate is about to become the most measured female in history Related
18 August
Founder and former CEO of Zynga, the social-games company behind FarmVille, Zynga Poker and Words with Friends; says he founded ten companies in all, and wrote Life at the Speed of Play.
. @yurimilner was that world class investor. After one meeting he said he wanted to invest and asked me for a valuation. I threw out a number 10 pct below what i figured our next round would be. He said he would wire the money next week. I think it was $150m. Never asked for board seat or any terms. He ttly got what the founder of a high growth company cared about. No meetings. No terms. Dont bother us. Let us cook! Quoting @kevinleeme Whenever other founders ask me who my best investors are and who I’d recommend they work with, I name the handful of VCs who rarely bother us and trust us to operate. It’s funny how simply doing nothing as an investor can put you in the top 1% of a founder’s book. Related
23 July
Dutch bootstrapper who builds and runs their internet startups alone — Nomads.com, Remote OK, Hoodmaps, Photo AI and Interior AI — and has written about it at levels.io since 2013. Posts as @levelsio.
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related get a Weber Genesis gas bbq so you can always cook food, fun with friends too
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levels.io
21 July
Experimental psychologist and author of the blog Experimental History, on psychology, science reform and creativity.
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"How to Survive Boiling Water" is a quintessential effort post. Cook accidentally drinks some probiotic tea, and then she's like, wait, how could "probiotic tea" possibly be a thing?
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experimental-history.com
28 May
Climate journalist; founded HEATED in 2019 after reporting on climate at The New Republic and ThinkProgress.
7 May
Professor of finance at NYU's Stern School of Business, known for his work on valuation. He publishes his data, spreadsheets and classes free at Damodaran Online and writes the Musings on Markets blog.
Tim Cook will be stepping down as CEO of Apple on Sept 1, 2026, after fifteen years atop the company. He has been critiqued for being too cautious, but I celebrate his restraint in my post on his tenure. bit.ly
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6 May
Professor of finance at NYU's Stern School of Business, known for his work on valuation. He publishes his data, spreadsheets and classes free at Damodaran Online and writes the Musings on Markets blog.
An Ode to Restraint: Lessons from the Tim Cook Legacy! Related
25 April
Writes Stratechery, a subscription newsletter on the business and strategy of technology, and hosts the Dithering and Sharp Tech podcasts.
Best Cook take of the week Quoting @drbarnard After way too many nauseatingly positive takes on Cook’s tenure, this is exactly the post I needed to close out the week. 👏 @andrewsharp (and by extension, @benthompson) Related
16 December 2025
China economy researcher based in Beijing who writes on his personal blog about Chinese political economy, history, books and music.
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The causes and meaning of those events have been debated ever since, and Sides delivers a careful, sympathetic and engaging account of the entirety of Cook's final expedition.
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andrewbatson.com
28 November 2025
Writer and illustrator, author of Am I There Yet? and Out of the Blue; writes the newsletter Out of the Blue on grief, joy and everyday attention.
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The Everlasting Meal taught me how to cook with instinct, which is my most cherished skill!
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mariandrew.substack.com
17 November 2025
Managing partner at Ritholtz Wealth Management. Writes the blog The Irrelevant Investor and co-hosts the Animal Spirits podcast with Ben Carlson.
If this is the end for Tim Cook, his run will go down in history. Over $700 million of market cap has been added on average every day since he took over as CEO in 2011. Chart by @mattcerminaro Related
1 November 2025
Novelist and writer, author of Mr. Penumbra's 24-Hour Bookstore and Sourdough; previously worked at Twitter and Current TV.
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Thermoworks Thermapen One I cook a lot of meat, and I am devoted to the meat thermometer; cooking without one feels like flying blind.
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robinsloan.com
29 April 2025
Genomics researcher and writer on science, biotech and the culture of research.
18 July 2023
Engineering leader and writer on web operations and resilience engineering; formerly SVP of Technical Operations at Etsy and co-author of Web Operations.
"It all started at Three-Mile Island" - episode 1 of @ri_cook's Cognitive Work Studies seminar youtube.com
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