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Jacob Trefethen Blog
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12 September
10 June
From one piece “Curing All Disease by next century is too conservative" - Mark Zuckerberg 2 beliefs, in the piece's order there
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Their words
rather than studying the specific diseases we think that by trying to understand inflammation more broadly that will make it so that other companies that can then use these tools can work on specific therapies.
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korrents.com
The point is not to cure diseases but to build the tools with which the whole scientific field cures them.Their words
And again, I mean, the the theory isn't that we're going to cure the diseases. We're not. um it's that we want to help accelerate the pace of progress for the whole scientific field.
28 February
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Lastly, the duration of a clinical trial does not merely determine how fast an individual therapy reaches patients. It also shapes which diseases attract serious investment and which do not.
29 January
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korrents.com
Aging is neglected not for technical reasons but because it is not yet socially classified as a disease.Their words
I think longevity and aging kind of occupy this weird realm where because they're not like explicitly diseases in a way that's fully socially recognized yet they're not seen as valid to work on but like that's not really for I think technical reasons on some level it's more for like classification reasons
30 September 2025
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No, I'm not saying that you should never take pills. There are obviously some diseases that you can only fight with antibiotics, for example. So, I'm not suggesting we go back to the Middle Ages, but what I'm saying is we overuse pills.
2 August 2025
From one piece AI will not suddenly lead to an Alzheimer's cure 2 beliefs, in the piece's order there
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Research predominance in rich countries leads to skewed knowledge and product availability.
AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com
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Measles is technologically “solved”, but not everyone trusts the solutions or their messengers.
AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com
11 July 2025
29 May 2025
From one piece A Quantitative Approach to Vaccine Funding 2 beliefs, in the piece's order there
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Infectious diseases as a category receive vastly less R&D spending from industry than non-communicable diseases, per death they cause, because they disproportionately kill people in lower- and middle-income countries where the payoff for making a cure is less lucrative.
A Quantitative Approach to Vaccine Fundingblog.jacobtrefethen.com
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Our punchline is that R&D spending varies by 10X+ across diseases for no good reason. I've been poking at that punchline for the last six or so years, from different directions, and I am confident it's true.
A Quantitative Approach to Vaccine Fundingblog.jacobtrefethen.com
8 May 2025
30 September 2024
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korrents.com
Spain and Portugal are unfairly maligned by the Black Legend: it was the diseases that killed the Americas.Their words
I think that the Spanish and the Portuguese get unfairly maligned in what’s been called the Black Legend, that they just marched into America and murdered everyone. That’s not the fact. It was the diseases that murdered everyone.
2 January 2024
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korrents.com
The long decline in mortality is not guaranteed to continue: new shocks and old unsolved diseases can reverse it.Their words
None of these trends are a given.
23 December 2023
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Because patents have fixed term lengths, with small extensions to compensate for the year or so when the drug is under regulatory review, drug developers are incentivized to go after conditions where clinical trials can be completed quickly, all else being equal.
28 November 2023
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And I notice that the tiny handful of people capable of caring about 200,000 people dying of neglected tropical diseases are the same tiny handful of people capable of caring about the next pandemic, or superintelligence, or human extinction.
In Continued Defense Of Effective Altruismastralcodexten.com
28 May 2019
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Recommendsaffiliate linkrcmnd.app
Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform IndustriesTheir words
Safi Bahcall, Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform Industries: How does group behavior and the science of phase transitions manifest itself? The author, a physicist and entrepreneur, tries to show why some wild new ideas become game changers. I was skeptical, but when someone like Danny Kahneman claims “This book has everything: new ideas, bold insights, entertaining history and convincing analysis. Not to be missed by anyone who wants to understand how ideas change the world,” I pay attention.
12 January 2017
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Recommendsrcmnd.app
the work of Dr. Sarah BallantyneTheir words
If you suffer one of those diseases, in addition to talking to your doctor, I recommend the work of Dr. Sarah Ballantyne. She has a PhD in medical biophysics, and managed to cure four of her own severe autoimmune diseases with the autoimmune protocol.
1 March 2015
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