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Bryan Johnson x.com
Old female mice on semaglutide lived 12% longer and ran 2.8× as long before exhaustion. Other gains: > treadmill time to exhaustion +177% > hanging time +124% > rotating-rod performance +47% > open-field movement +50% > glucose tolerance: area under the curve −20% > Improved spatial memory: maze escape time −57% > reduced inflammation -55% > reduced senescence -65% > stem cell rejuvenation: hippocampal neurons ~3x > bone marrow colonies +44% > DNA damage & stress -44% Treatment started at 20 months of age (human equivalent to 60s). Control was a separate group of mice on a 24% food restrictio…
semaglutideglucoserejuvenation
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It's showing us that apathetic people use more brain energy when they're making this decision. They have a bigger activation energy barrier to overcome because when they're making that decision, the brain is consuming more energy. It's consuming more glucose when it's doing that.
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In rodent studies, semaglutide and tirzepatide were both found to increase the rate of thyroid tumors.
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