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semaglutide mice lifespan
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18 September
Entrepreneur and founder of Blueprint. Publishes a detailed, freely available longevity protocol documenting the food, supplements, devices and measurements he uses on himself.
Old female mice on semaglutide lived 12% longer and ran 2.8× as long before exhaustion. Other gains: > treadmill time to exhaustion +177% > hanging time +124% > rotating-rod performance +47% > open-field movement +50% > glucose tolerance: area under the curve −20% > Improved spatial memory: maze escape time −57% > reduced inflammation -55% > reduced senescence -65% > stem cell rejuvenation: hippocampal neurons ~3x > bone marrow colonies +44% > DNA damage & stress -44% Treatment started at 20 months of age (human equivalent to 60s). Control was a separate group of mice on a 24% food restrictio… Related
26 August
Creator of Ruby on Rails, CTO of 37signals, and creator of Omarchy.
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I actually I do wanna die. I don't wanna do this forever. Like, I think the human li- lifespan of about 90 to 100 sounds about right. I'm embracing the finitude of life.
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youtube.com
14 August
Graphic designer and type designer, who created the original Macintosh icons and typefaces at Apple from 1982 and has since designed interface graphics for NeXT, Microsoft, Facebook and Pinterest.
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But again, too much detail. It would have had a much longer lifespan if I had just stopped and made it simpler.
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youtube.com
27 April
Author of Recoding America; founded Code for America and was US deputy chief technology officer from 2013 to 2014. Writes Eating Policy on why governments cannot do what they decide to do.
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Extending the lifespan of a brittle system just means the system eventually fails more spectacularly.
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eatingpolicy.com
28 February
Genomics researcher and writer on science, biotech and the culture of research.
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But remember that such data can only come from trials in people (mice are nice, but most animal results simply do not translate.)
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writingruxandrabio.com
24 December 2025
Writes Nintil, long researched essays on metascience, biology, economics and whatever he has decided to read the literature on.
13 October 2025
Freelance research analyst and writer of the blog Aceso Under Glass, known for 'epistemic spot checks' of non-fiction claims.
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In rodent studies, semaglutide and tirzepatide were both found to increase the rate of thyroid tumors.
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acesounderglass.com
8 June 2025
Software engineer; co-founder and former CTO of Tailscale, previously on the Go team at Google.
20 April 2024
Researcher and science writer. Co-founder and editor at Works in Progress magazine, formerly a researcher at Our World in Data, and author of the Scientific Discovery newsletter on science, global health and medical innovation.
16 March 2024
Researcher and science writer. Co-founder and editor at Works in Progress magazine, formerly a researcher at Our World in Data, and author of the Scientific Discovery newsletter on science, global health and medical innovation.
Many great things you missed this year This week: Birth seasonality, causes of death across the lifespan, progress against HIV/AIDS & cystic fibrosis, very rare infectious form of Alzheimer’s, improvements in cholesterol, and more.
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14 June 2022
Psychiatrist and clinical assistant professor at Case Western Reserve University. Writes Psychiatry at the Margins on the philosophical and scientific arguments inside psychiatry and the psy-sciences.
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