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To me, the possibility of partnership is the feeling that despite the fundamental chasm between two human beings, love allows us to bridge the gap; alienation is the feeling that the gap cannot be bridged, and moreover, that I do not want to.
For postmenopausal women—and women with premature estrogen deprivation for other reasons—vaginal estrogen is a safe and highly effective therapy to alleviate the genitourinary syndrome of menopause, prevent recurrent UTIs, and likely to save lives.
If you suffer from amygdala hyperactivity that gives you one of the aforementioned psychiatric disorders, I think that not only should you be offered elective amygdalectomy, but your health insurance should be glad to pay for it (especially if done via ultramodern very safe radiosurgery) one time, rather than for a lifetime supply of more expensive, less effective talk therapies and medications.
It may not be stored there, but what you're tapping into, it's not a repository of the memory, but it's part of this mind-body feedback loop where there's a sensation that your brain has an association to that might have a familiarity to a time in which you felt sad or scared.
The phrase "your feelings are valid" does not invite curiosity or deeper self-understanding, which is the point of psychotherapy. It is the mirror image of "stop whining and get a grip." One sounds warm and one sounds harsh, but neither deepens self-awareness.
There are many practices that promise to transform and improve us-therapy, meditation, psychedelics-, but that branding doesn't mean that they actually do much for us: it is common to see people use these techniques for years without any obvious progress on their problems.
Excessive manufacturing requirements are a pervasive problem, especially in the field of cell and gene therapy and they are killing countless of promising medicines before they ever reach patients.
Until manufacturing and regulatory risks become easier to underwrite, capital will keep drifting away from one of the most promising technologies of the last century.
Lastly, the duration of a clinical trial does not merely determine how fast an individual therapy reaches patients. It also shapes which diseases attract serious investment and which do not.
The ORS is a brief, 4-item measure designed to assess areas of life functioning known to change as a result of therapeutic intervention. It takes less than one minute to complete and score.
The SRS is a brief, 4-item measure designed to assess the therapeutic alliance. It provides immediate feedback on the quality of the relationship and allows for course correction in real time.
Best books I read in 2025: Just a note that these books weren’t all necessarily published this year (though some were). A Story is a Deal: How to use the science of story to motivate and persuade by Will Storr Bringing Up Baby: An Evolutionary View of Pediatrics by Paul Turke Bad Therapy: Why the Kids Aren’t Growing Up by Abigail Shrier
Likewise, self-diagnosis should be understood as an attempt to secure the therapeutic effect of a medical intervention to which patients do not have official access.
If a clinical diagnosis can have a therapeutic effect, then, at least in some instances, diagnoses are medical interventions in themselves and ought to be treated and researched as such, with an eye to both positive effects and potential iatrogenic harms.
Their experiences highlight a striking, neglected and unchristened medical phenomenon: The therapeutic effect of a clinical diagnosis, independent of any other intervention, where clinical diagnosis refers to situating the person's experiences into a clinical category by a clinician or the patient.
It's like trying to find meaning in your job. You can find satisfaction in what you do. That is a very good thing. You can find satisfaction and be happy with what you've created. You can be thrilled by the experience, but you cannot find... I doubt you can find purpose.
If one really wanted to know whether a treatment (e.g., CBT, IPT, ACT, EMDR) was more effective, it had to be directly compared to an approach intended to help - what Wampold and colleagues termed, a "bona fide" treatment. Doing otherwise, they argued, conflated artifacts of research design with actual research results.
Since 2012 when the first study appeared in the literature, others have been published documenting the tendency of practitioners to overestimate their effectiveness - on average, by 65% (1, 2).
It turns out that therapists who perform well on the FIS establish stronger relationships and are more effective (2). More to the point, the evidence shows FIS-related skills are trainable and that such training leads to better results (3, 4, 5).
Over the last 50 years, treatment methods have proliferated despite a lack of evidence of differential effectiveness between approaches. And even when a randomized controlled trial indicates a particular approach works, none show practitioners become more effective when they are trained in that modality.
Indeed, as I've reported in previous posts, research not only shows therapists do not improve with time and experience in the field, but on average become less effective (1, 2, 3, 4).
In my practice, I have seen that opening neural pathways can lead to profound change, to brand-new traits and behavior, sometimes in a matter of minutes.
Tomorrow, and Tomorrow, and Tomorrow resonated with me for personal reasons, but I think Zevin’s exploration of partnership and collaboration is worth reading no matter who you are.
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