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korrents.com
AI-assisted biological research still depends on physical wet-lab work that remains a necessary bottleneck for now.Their words
This physical work will remain necessary for the foreseeable future.
What AI can and cannot do in biosecurityyourlocalepidemiologist.substack.com
Related posts
Patrick O'Shaughnessy Podcast
Matthew Smith — Natural Gas: The Next Bottleneck - [Invest Like the Best, EP.483]
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16 September
15 September
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korrents.com
What limits AI automating a workflow is how well the workflow is codified, not the underlying modelTheir words
The bottleneck is not the model, it is the codified workflow.
8 September
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Their words
the new bottleneck in software engineering: review, testing and QA
4 September
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korrents.com
The biggest problem in robotics today is data, not chips; chips become the bottleneck later.Their words
We should zoom out and recognize the biggest problem right now in robotics is actually data. One day it'll be chips, but for now it's data.
1 September
12 August
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korrents.com
In California, lack of money is not what stops public beautification projects from getting built.Their words
The client was hoping for an instruction manual on buying beauty, but at least in California, money isn't the bottleneck.
11 August
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korrents.com
The least verifiable part of AI research is the judgement call about what goes into the one big training run.Their words
Like the thing that I think is most likely to be sort of the bottleneck in terms of like the AI are really good at verifiable domains but not not at doing the actual thing is just like big experiments. You only get a few tries um well a few is maybe a bit understated but like basically like historically R&D has been driven by doing near frontier scale experiments and that has been pretty important and like actually doing the one big training run where you decide exactly what to include in that.
10 August
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Their words
So we conjectured that the lack of data was a huge part of the reason that's the lack of progress in AI. So we took a departure from everybody else who are really focusing only on algorithm and said that we need data. we need data to drive these algorithms.
7 August
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Their words
And so we can distribute the voting across a lot of the company for this initial review, which is essential because if you're doing anything cool, by the time you get a couple years into it, that top of funnel is overwhelming. And if you place any in any small group of employees or any one person in the way as a bottle bottleneck on this, they will absolutely bottleneck the whole rest of the organization.
29 July
From one piece Alexandr Wang: “This is a Once-in-a-Civilization Opportunity” 2 beliefs, in the piece's order there
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Their words
I mean, I think for the history of humanity, um you know, groups of smart people getting together towards a shared goal was was the bottleneck of progress. You know, US The United States of America in some sense was an example of this. Like the United States of America was formed from a smart group of very smart people getting together and having a vision for the future that they wanted to enact.
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Their words
I think we're at this like in amazing moment in the world where the bottleneck is not the progress of the AI models, the bottleneck is diffusing that through the rest of the world and and helping the world adapt to this amazing technology that already exists. Like I think if the models didn't improve at all from today, there would still be like decades and decades of like total upheaval and change in the economy and how the world operates and and everything around us
21 July
5 July
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korrents.com
AI has made ability nearly free, making taste the main bottleneck separating good creators from mediocre ones.Their words
As AI has allowed more and more people to create things, the biggest differentiation, the biggest skill people are lacking, is taste itself.
26 June
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Their words
and I don't think we're headed to that world largely because of the fact that the models rely so much on large scale test time compute in order to achieve um their greatest intelligence. If you if it requires so much test time on compute to unlock the full capabilities of the model, then that means you're bottlenecked by time
18 June
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Their words
So I think power, thermal, those become the bottleneck. So I think I always look at from what is the problem we try to solve? Is it real? Is customer crying for it?
3 June
3 May
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Their words
The bottleneck has shifted from doing the work to writing clear specs and reviewing outputs fast enough to keep the pipeline moving-the middle is hollowing out.
26 April
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Their words
for us design actually has always operated as like a bottleneck at the company, which is incredibly important, right? It's intentional that things need to be approved by design to ship.
22 April
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korrents.com
AI-written code makes formal proof necessary, because human review of all that generated code becomes the bottleneck.Their words
But also LLMs increase the need for these formal proofs because, you know, we're live coding a bunch of stuff. If we have to manually review all of that code, then that will become the bottleneck.
16 April
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korrents.com
The real bottleneck in product work is discovering a solution worth building, not building it.Their words
Now, it’s clear that the real bottleneck is in discovering a solution that’s worth building.
15 April
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Their words
And so none of that my point is that none of the bottlenecks last longer than a couple 2 three years. None of them.
7 April
From one piece Michael Nielsen – Why aliens will have a different tech stack than us 2 beliefs, in the piece's order there
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Their words
So certainly one thing that a lot of them seem to be bottlenecked on is now having interesting ideas and in particular having interesting design ideas.
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Their words
the point is that where we always get bottlenecked is where the the previous processes and and and heuristics don't apply. Right? Like that's almost sort of definitionally what causes the bottlenecks.
25 March
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Their words
With an orchestrated army of agents, there is no bottleneck, no human pain. These tiny little harmless booboos suddenly compound at a rate that's unsustainable. You have removed yourself from the loop, so you don't even know that all the innocent booboos have formed a monster of a codebase. You only feel the pain when it's too late.
22 March
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Their words
And not only that, but like humans were already a bit of a bottleneck in the review process. Now it can be worse because things that we fairly straightforward changes that some companies had automation around reviewing, they've removed that reviewing because if AI is involved and they're worried about the verifiability or the reliability of the code.
13 March
From one piece Dylan Patel — The single biggest bottleneck to scaling AI compute 2 beliefs, in the piece's order there
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Their words
So to scale compute further right there's some different bottlenecks this year next year uh but ultimately by 2829 the bottleneck falls to the lowest rung on the supply chain which is ASML right ASML makes the world's most complicated machine i.e. an EUV tool.
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Their words
Yeah, I think the biggest bottleneck is compute and for that the longest lead time supply chains are not power or data centers. They're actually the semiconductor supply chain themselves, right? It switches back from being power and data center uh as a major bottleneck to chips.
15 August 2025
From one piece China is killing the US on energy. Does that mean they’ll win AGI? — Casey Handmer 2 beliefs, in the piece's order there
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Their words
And the bottleneck prior to what we call the industrial revolution was uh metabolism, right? It's just like how much like oats can a human or a horse physically digest and then convert into useful mechanical output for you know their their um their peasant overlord or whatever.
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Their words
They're focused on the chips, right? Because they understand like the key bottleneck is the chips, not the solar power, right?
2 August 2025
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korrents.com
Not every bottleneck on medical progress is one AI can remove, and which ones will remain can be guessed at now.Their words
But I don’t think all bottlenecks on medical progress are equally AI-able in the next decade, and I don’t think all will become irrelevant.
What does AI progress mean for medical progress?blog.jacobtrefethen.com
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Their words
Measles is technologically “solved”, but not everyone trusts the solutions or their messengers.
AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com
19 April 2025
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Their words
People who can be trusted to make something inevitable are really rare, and are typically the bottleneck for how many different things a team or company can do at once.
22 March 2025
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Their words
Most of the time I'm not thinking, I'm programming. I know what I want to do, I want to go as fast as possible because I've been just doing it for so long and I'm so familiar with the general space that it becomes a huge problem for me. I cannot tell you how many times that I've been purely bottlenecked by the fact that I just can't type fast enough and I just need to get it out of my head onto the text editor.
16 March 2025
3 February 2025
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Their words
Interesting thing is certain regions of the US transmitting power cost more than actually generating it because the grid is so slow to build. And the demand for power, and the ability to build power, and re-ramping on a natural gas plant or even a coal plant is easy enough to do, but transmitting the power's really hard.
17 September 2024
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Their words
Another challenge for Class II biotechs is that even if you have a nifty computational drug discovery platform, you are still often bottlenecked by the rest of the drug development process. It takes 1,000 (or more!) small steps to advance a drug through discovery, development, and past the regulators.
13 July 2024
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