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Cardiologist and founder of the Scripps Research Translational Institute; writes Ground Truths on biomedical research, and wrote Super Agers and Deep Medicine.

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  A drug that moves a surrogate blood marker in the right direction cannot be assumed to prevent heart attacks and strokes.

  Their words

  We can’t count on surrogate blood markers to guide the results of cardiovascular clinical outcome trials.

  The Coronary Artery Inflammation Controversyerictopol.substack.com

Writes Don't Worry About the Vase, a near-daily account of what is happening in AI and what they think it means. Former Magic: the Gathering pro and trader; unusually willing to put a number on a belief and to grade their own past calls.

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  An AI model's attempt to escape a testing environment or sandbox counts as an alignment failure even when the attempt does not succeed.

  AI alignment

  Their words

  Every attempt, even an unsuccessful one, is an alignment failure.

  Anthropic Has Some Alignment Problemsthezvi.substack.com

Danish software engineer and Microsoft technical fellow, creator of Turbo Pascal and Delphi and lead architect of C# and TypeScript.

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  Function colouring is the real cost of async/await, and green threads like Go's avoid it — but for an existing runtime such as JavaScript or C#, async/await was still the right solution.

  JavaScript

  Their words

  So that's unfortunate, and that's why some environments like Go, for example, has has Go routines and green threads, which are really language emulated lightweight threads that kind of do what I'm talking about, but but at a much lower cost. But you avoid the function coloring. So there is a bunch of different things, but but you know, but for an environment that already exists like JavaScript or like C# and and the Windows event loop and and whatever, this this was the right solution.

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Scientist and writer on quantum computing, memory systems and metascience; co-wrote the standard quantum computation textbook and wrote Reinventing Discovery.

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  Anomalies cannot be sorted in advance: the same move that found Neptune failed completely for Mercury, so a field has to pursue both answers at once.

  Their words

  And so you sort of you've you've pursued very similar ideas. It's been very successful in one case and it's been completely and utterly unsuccessful in the other case. And I think I mean a priori, you can't tell which of these is the thing to do. And you actually need to do both.

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Chilean web engineer building web experiences since 2006; co-founder of Media Creators and writes at iolivares.com.

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  ErgoFoam Fit Mesh

  Their words

  After 5 unsuccessful purchases of gamer chairs. The best is an ergonomic chair and this is the best.

  iolivares.com