Eric Topol
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27 October
11 October
6 October
30 September
From one piece Loss of Cell Identity Drives Human Aging 3 beliefs, in the piece's order there
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Their words
It follows that lifestyle factors, like a pro-inflammatory diet, lack of exercise, or poor sleep quality, can be viewed as chronic stressors that could promote the slow layer erosion and accelerate the loss of cell identity.
Loss of Cell Identity Drives Human Agingerictopol.substack.com
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korrents.com
Epigenetic aging clocks measure the pace at which the slow, identity-locking layer of the cell erodesTheir words
Epigenetic clocks are remarkably informative across 348 mammalian species, including humans, for predicting maximal lifespan and life history, but we didn't know what they are actually measuring. It turns out it's PRC2, the pace of slow layer erosion!
Loss of Cell Identity Drives Human Agingerictopol.substack.com
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Their words
Undoubtedly, loss of cell identity is a major underpinning of age-related diseases.
Loss of Cell Identity Drives Human Agingerictopol.substack.com
19 September
From one piece The Big Holes in Wearable Heart Rate Variability And Readiness Scores 2 beliefs, in the piece's order there
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Their words
From the points I've gone over above, we're not ready for readiness scores. Besides being proprietary, they are predominantly based on metrics that have their own issues.
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Their words
An important reminder is that HRV is a surrogate marker without any established cause-and-effect relationship. If you increase your HRV, that doesn't mean it will improve health outcomes.
14 September
5 September
From one piece The Coronary Artery Inflammation Controversy 3 beliefs, in the piece's order there
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Their words
We know that arteries with a calcium (CAC) score of zero can be highly inflamed, and that high CAC scores are not necessarily high-risk for cardiovascular events.
The Coronary Artery Inflammation Controversyerictopol.substack.com
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Their words
The “inflammation hypothesis” is not a hypothesis.
The Coronary Artery Inflammation Controversyerictopol.substack.com
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Their words
We can’t count on surrogate blood markers to guide the results of cardiovascular clinical outcome trials.
The Coronary Artery Inflammation Controversyerictopol.substack.com
30 August
23 August
12 August
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Their words
The original brain microglia (Micro1) are replaced by transformed monocytes (Micro 2) that are highly inflammatory.
4 August
20 July
12 July
From one piece Medicine is Moving From Calendars to Clocks 4 beliefs, in the piece's order there
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Their words
I would suggest not buying any of these tests.
Medicine is Moving From Calendars to Clockserictopol.substack.com
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Their words
I believe this represents the most important advance we have yet seen in the science of human aging.
Medicine is Moving From Calendars to Clockserictopol.substack.com
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Their words
Accordingly, the brain and immune system have the appearance of master regulators of the aging process.
Medicine is Moving From Calendars to Clockserictopol.substack.com
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korrents.com
Our organs and cell types age at different rates, so a single chronological age is an illusion.Their words
It also turns out our organs age at a different pace.
Medicine is Moving From Calendars to Clockserictopol.substack.com
3 July
26 June
17 June
13 June
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Their words
Once we can accurately predict cancer 5+ years ahead, the era of primary prevention will go into high gear.
6 June
24 May
14 May
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