Alex Telford
Everything, newest first — across every channel. Their profile →
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7 December 2025
3 August 2025
20 December 2024
From one piece Will all our drugs come from China? 2 beliefs, in the piece's order there
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korrents.com
China now starts about a quarter of the world's new clinical trials, more than Europe does.Their words
Chinese companies are now responsible for about a quarter of new trial starts — more than Europe.
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Their words
I don’t think many in the West have yet fully internalized a mental model of China as a source of genuine innovation.
17 September 2024
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Their words
Another challenge for Class II biotechs is that even if you have a nifty computational drug discovery platform, you are still often bottlenecked by the rest of the drug development process. It takes 1,000 (or more!) small steps to advance a drug through discovery, development, and past the regulators.
1 April 2024
23 December 2023
From one piece The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it 9 beliefs, in the piece's order there
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korrents.com
Regulatory and social tolerance for drug risk falls over time, and the ratchet is almost never loosened.Their words
it seems to be broadly true that regulatory and societal tolerance for risk declines with time
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Their words
it will take time for deep learning systems and training data to mature enough to be useful for the truly value-adding task of predicting safety and efficacy in humans
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Their words
Because patents have fixed term lengths, with small extensions to compensate for the year or so when the drug is under regulatory review, drug developers are incentivized to go after conditions where clinical trials can be completed quickly, all else being equal.
+ 6 more
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korrents.com
Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour.Their words
Clinical trials are expensive because they are complex, bureaucratic, and reliant on highly skilled labour.
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Their words
Biology is unpredictable, especially when the immune system is involved, and there is no guarantee that a drug that appears safe in animals will be safe in humans.
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Their words
The most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make.
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Their words
The cost to discover and develop a drug today is orders of magnitude higher than in the 1950s. Despite this, the probability that a drug entering clinical trials will eventually reach the market has hardly improved in the intervening years.
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Their words
In reality, the productivity crisis in the pharmaceutical industry is the culmination of decades of just about every aspect of drug discovery and development getting gradually harder and more expensive.
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Their words
Such prolificacy is unlikely to be repeated any time soon; if current trends hold, a drug discovery scientist starting their career today is likely to retire without ever having worked on a single drug that makes it to market.
17 November 2023
11 October 2023
24 August 2023
17 May 2023
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