Ruxandra Teslo
Everything, newest first — across every channel. Their profile →
Hiding
18 September
1 September
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korrents.com
Curing disease is not worth it if the price is the permanent deprecation of most human beings' existence.Their words
As someone coming from a biology background, who considers “curing disease” as a very noble mission, I still believe that the vague promise of “curing disease” is fundamentally not worth it if it comes with a form of permanent deprecation of most humans’ existence.
21 July
From one piece Intelligence is not the main bottleneck 6 beliefs, in the piece's order there
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Their words
That is mostly in the realm of chemistry and is intrinsically far more tractable and predictable; given a validated target, good teams usually reach a decent molecule.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
Take Eroom’s Law: the number of new drugs approved per dollar of R&D has fallen for decades, even as our scientific tools have grown vastly more powerful, the exact opposite of what the existence of more raw capability would predict.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
A capability existing is not the same as a capability being absorbed into institutions, and, perhaps most important of all, translated into outcomes people care about.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
The patent system then further disincentivizes companies from taking target risk, because it rewards novel chemical matter, not novel biology.
Intelligence is not the main bottleneckwritingruxandrabio.com
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korrents.com
Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be.Their words
In biomedicine we have a problem called target herding: most companies chase the same biological targets because they are de-risked, which means we explore far less of the biological space than we could.
Intelligence is not the main bottleneckwritingruxandrabio.com
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Their words
I told him what I believe: that in the age of AI, medicine will be bottlenecked more than ever by regulation and the grind of clinical trials, and that billions poured into faster pre-clinical research won’t touch that problem, unsexy as it is.
Intelligence is not the main bottleneckwritingruxandrabio.com
10 June
From one piece Manufacturing requirements are killing cell and gene therapy 2 beliefs, in the piece's order there
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Their words
Until manufacturing and regulatory risks become easier to underwrite, capital will keep drifting away from one of the most promising technologies of the last century.
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korrents.com
Manufacturing and batch-release requirements, not biology, are what kill most promising cell and gene therapies.Their words
Excessive manufacturing requirements are a pervasive problem, especially in the field of cell and gene therapy and they are killing countless of promising medicines before they ever reach patients.
12 April
15 March
11 March
3 March
28 February
From one piece A response to Dario Amodei on AI & clinical trials 5 beliefs, in the piece's order there
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Their words
The current success rate for a drug entering clinical trials is only about ten percent, meaning 90 percent of all drugs fail.
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Their words
Lastly, the duration of a clinical trial does not merely determine how fast an individual therapy reaches patients. It also shapes which diseases attract serious investment and which do not.
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Their words
But remember that such data can only come from trials in people (mice are nice, but most animal results simply do not translate.)
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Their words
Trials serve two distinct functions: validation — confirming whether a drug works and is safe — and learning, or generating biological data to refine our understanding of a disease, a compound, and the relationship between the two.
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Their words
Even if AI can help design more effective drugs, timelines will not compress until we solve the operational and regulatory bottlenecks of trials.
18 February
11 February
6 December 2025
9 November 2025
18 September 2025
4 September 2025
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23 August 2025
29 April 2025
20 April 2025
18 April 2025
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