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Technology writer of Spyglass, a newsletter about technology and media. Previously a reporter at TechCrunch and an investor at GV.

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  A CEO's command of facts and thoughtful, unscripted answers signals real leadership more than charisma does

  Their words

  one of the things that made Steve Jobs, Steve Jobs, was how in command he was of the facts - yes, even those sprinkled with reality distortion dust! - on stage.

  The Apple Naturalspyglass.org

Co-founder and CEO of OpenAI; previously president of Y Combinator.

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  Concentrated power has been bad at every moment of human history, and a society is best off when power is spread as widely as possible.

  startups

  Their words

  I think concentration of power has basically been bad in every moment of human history um to varying degrees of course but I have a real spirit and I think this is part of the startup spirit of thinking that the world, the economy, society is the best off when power is very widely distributed

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Genomics researcher and writer on science, biotech and the culture of research.

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  AI will not on its own compress decades of medical progress into a few years, because the binding constraint is human data, clinical trials and regulation rather than intelligence.

  Their words

  I told him what I believe: that in the age of AI, medicine will be bottlenecked more than ever by regulation and the grind of clinical trials, and that billions poured into faster pre-clinical research won’t touch that problem, unsexy as it is.

  Intelligence is not the main bottleneckwritingruxandrabio.com

Machine learning engineer and consultant focused on RAG and retrieval systems. He writes about applied AI engineering at jxnl.co and is the author of the instructor library.

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  Storing an AI agent's memory as files forces it to compress what it learns into a form that survives even when the conversation itself doesn't.

  Their words

  Files force the agent to compress experience into a form that can survive the thread.

  Codex-maxxingjxnl.co

Genomics researcher and writer on science, biotech and the culture of research.

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  Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.

  Their words

  Even if AI can help design more effective drugs, timelines will not compress until we solve the operational and regulatory bottlenecks of trials.

  writingruxandrabio.com

Writer and illustrator behind Wait But Why, a long-form blog of stick-figure-illustrated explainers on science, technology and society, and author of the book What's Our Problem?

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  Most people are not genuinely interested in videos of someone else's young child.

  Their words

  Toddler parenthood is a reality distortion zone that makes it hard to remember that most people find your toddler breathtakingly uninteresting.

  Tales from Toddlerhoodwaitbutwhy.com

Founding member of OpenAI and former director of AI at Tesla; creator of nanoGPT and the term "vibe coding".

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  Models are enormous only because the internet is bad: most of that capacity does memory work, and a better dataset would need far less of it.

  Their words

  Um so I almost feel like because the internet is so terrible, we actually have to sort of like build really big models to compress all that. Uh most of that compression is memory work instead of like cognitive work. But what we really want is the cognitive part actually delete the memory

  youtube.com

Runs global health R&D at Open Philanthropy; writes about the science and medicine that could exist and does not.

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  AI will not on its own compress decades of medical progress into a few years, because the binding constraint is human data, clinical trials and regulation rather than intelligence.

  Their words

  Those are why I do not believe that AI could end disease within 10 years on its own, nor that 50-100 years of medical progress could occur 5-10 years after powerful AI due to AI progress alone

  AI will not suddenly lead to an Alzheimer's cureblog.jacobtrefethen.com

Co-founder and CEO of Anthropic; previously VP of research at OpenAI.

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  Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years.

  Their words

  To summarize the above, my basic prediction is that AI-enabled biology and medicine will allow us to compress the progress that human biologists would have achieved over the next 50-100 years into 5-10 years.

  Machines of Loving Grace (October 2024)darioamodei.com

Engineer and writer on machine-learning systems; author of Designing Machine Learning Systems and AI Engineering. "I work to bring AI into production. I write about AI system design."

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  As more AI models are developed with varying capabilities and costs, routing between them carries real economic value.

  Their words

  With more and more models being developed, each with different capabilities and a cost structure, model routing has clear economic values.

  huyenchip.com

Psychologist and science writer; wrote Science Fictions on how research goes wrong, and writes the newsletter of the same name.

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  Compressing a piece of research into a journal paper's word count is itself a distortion of what was found.

  Their words

  The mere act of squeezing a complex process into a few thousand words—limited by a journal-imposed word count—is itself a distortion of reality.

  Science isn't storytellingsciencefictions.org