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Genomics researcher and writer on science, biotech and the culture of research.

• Our readingkorrents.com

  The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.

  Their words

  That is mostly in the realm of chemistry and is intrinsically far more tractable and predictable; given a validated target, good teams usually reach a decent molecule.

  Intelligence is not the main bottleneckwritingruxandrabio.com

Dutch bootstrapper who builds and runs their internet startups alone — Nomads.com, Remote OK, Hoodmaps, Photo AI and Interior AI — and has written about it at levels.io since 2013. Posts as @levelsio.

• Our readingkorrents.com

  AI has equalised everyone: coding, building and execution are no longer a differentiator.

  Their words

  So AI has made everybody just as capable as everyone else, it equalized everyone in the world, as in everyone can make everything (software, music, images, art etc) now and everyone is equal, at least in the digital realm now

  levels.io

Co-founder and CEO of Until, a reversible-cryopreservation company, and previously the founder of the Longevity Fund.

• Our readingkorrents.com

  Aging is neglected not for technical reasons but because it is not yet socially classified as a disease.

  Their words

  I think longevity and aging kind of occupy this weird realm where because they're not like explicitly diseases in a way that's fully socially recognized yet they're not seen as valid to work on but like that's not really for I think technical reasons on some level it's more for like classification reasons

  youtube.com

Co-founder and chief executive of Figma, the collaborative design platform he started in 2012 and took public in 2025.

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  AI cannot get a product to the quality bar on its own, because it still works in the realm of averages.

  Their words

  And AI won't get you there alone. AI is uh still in the realm of kind of law of averages and uh better prompting can help of course

  youtube.com

Staff writer at The New Yorker, where he writes the Infinite Scroll column, and author of Filterworld and The Longing for Less.

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  People's desperate need to manipulate their own image, and their acceptance of being human-machine hybrids in the AI era, is reflected in current ugly, artificial-feeling consumer aesthetics.

  Their words

  I think this slop-adjacent realm of dupe products and Instagrammable potions points to our increasingly desperate need to manipulate our own images, and an acceptance of the fact that we're kind of hybridized monsters ourselves in this post-A.I. human-machine moment

  Labubus and the brainrot aesthetickylechayka.substack.com

Economist specialising in China's economy, international macroeconomics and global trade, and author of The New China Playbook.

• Our readingkorrents.com

  Tariffs will not fix what is wrong with global trade; they are a distortionary protectionist method and they will be bad for the country imposing them.

  China

  Their words

  Tariffs, this kind of highly protectionist method is very distortionary and it’s going to be bad for the US. I’d actually argue that both China and the US have totally taken advantage and also enjoyed the global economic realm under the US liberal order.

  youtube.com

Astrophysicist at Barnard College; wrote Black Hole Blues and How the Universe Got Its Spots, and directs sciences at Pioneer Works.

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  Wormholes are not yet an engineering problem, but they sit entirely within the realm of plausible physics.

  Their words

  That’s going to be really telling. So I’m not saying it’s simply an engineering problem, but it’s all within the realm of plausible physics, I think.

  youtube.com

Writer on a lost civilisation of the Ice Age; wrote Fingerprints of the Gods and presented Ancient Apocalypse. Archaeologists reject the claims, which he disputes at length.

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  Archaeology's hostility to him is territorial defence of a profession, and it grew with the size of his audience rather than with anything in his evidence.

  Their words

  I think it’s partly territorial. I cannot speak of all archeologists, but some archeologists feel very territorial about their profession. They do not feel happy about outsiders entering their realm, especially if those outsiders have a large platform.

  youtube.com

Science fiction novelist, journalist and technology activist; writes the daily blog and newsletter Pluralistic, and coined the term enshittification.

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  Platform decay is the result of specific decisions by identifiable people rather than impersonal historical forces, which is precisely what makes it reversible.

  Their words

  I think that the enshittification framework goes a long way to explaining it, moving us out of the mysterious realm of the 'great forces of history,' and into the material world of specific decisions made by named people – decisions we can reverse and people whose addresses and pitchfork sizes we can learn.

  My McLuhan lecture on enshittificationpluralistic.net