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19 September
Author and clean-energy analyst who writes on solar cost curves.
I, for one, am excited about China's progress and aspirations in designing new medicines. Pharma innovation is positive sum, and the benefits go overwhelmingly to patients and society, globally. Only a small fraction of the value is captured by producers or by the nation they hail from. A drug invented in China will cure me or someone I love just as well as one invented in the US or Europe. I do understand the fear in the US industry. And I hope that motivates us to accelerate the pace in the US, and pass some of regulatory reforms that @RuxandraTeslo and others have eloquently made the case… Quoting @fjeg1987 China wants its drugmakers to have originated 25% of first-in-class drugs and $522B in sales by 2030. This is compared to the total market of $800B today. I'm simultaneously in awe of the ambition and paranoid about the US ability to compete. I had a dinner with pharma leaders who remain delighted… Europe China Related
17 September
Author and clean-energy analyst who writes on solar cost curves.
This is beautifully written: An inspiring call to use AI to help understand, defend, and steward the biosphere that we depend on and are part of. Well done, Ryan. Quoting @orbuch I wrote an essay about why the next frontier for AI is the world outside the data center Nature is a system more complex than anything we've ever created AI can learn how the system fits together, so we can finally understand how to shape it How? Related
8 September
Chief AI Scientist at Databricks, after its acquisition of MosaicML, where he was a founding team member; known for the Lottery Ticket Hypothesis from his MIT PhD (ICLR 2019 Best Paper).
It’s always inspiring to see the AI community unified around the important, practical, last-mile challenges that will make AI adoption easier and improve everyday people’s lives. Related
7 September
Mathematician and Senior Lecturer in the Mathematics department at Columbia University. Author of the book Not Even Wrong and of the long-running physics blog of the same name.
5 September
Software engineer, Wikipedia editor and crypto critic; writes Citation Needed and runs Web3 is Going Just Great.
Huge congratulations to the US-based Wikimedia Foundation employees who voted with 92% support in favor of unionizing, and shoutout to the tireless work of the organizers. https://wikiworkersunited.org/announcements/2026-09-04-us-wikimedia-foundation-workers-overwhelmingly-vote-to-form-union-with-cwa/ #Wikipedia #WikimediaFoundation Related
31 August
Mathematical physicist at UC Riverside. Wrote This Week's Finds in Mathematical Physics and now the Azimuth blog on mathematics, physics and environmental science.
Don Zagier wrote: “There are two facts about the distribution of prime numbers of which I hope to convince you so overwhelmingly that they will be permanently engraved in your hearts. The first is that they are the most arbitrary and ornery objects studied by mathematicians: they grow like weeds among the natural numbers, seeming to obey no other law than that of chance, and nobody can predict where the next one will sprout. The second fact is even more astonishing, for it states just the opposite: that the prime numbers exhibit stunning regularity, that there are laws governing their behavio… people.mpim-bonn.mpg.de
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28 July
Co-founder and CEO of OpenAI; previously president of Y Combinator.
Their words
but I would I would bet that this generally will cut against many years of experience in favor of people who have a lot of fluency with the tools.
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youtube.com
19 July
Chief Product and Technology Officer at Netflix, previously VP of Science at Lyft and an economist at Analysis Group.
From one piece
Why Netflix is betting on systems thinkers—not specialists—in the AI era | Elizabeth Stone (CPTO)
2 beliefs, in the piece's order there
Their words
So, even in a world of AI where some things are easier, we were talking earlier about mindset, AI fluency. From my experience, younger folks are more open-minded. They tend to be more native in some of these new ways of working.
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youtube.com
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So, the most useful thing is not to make it level specific or role specific, but to encourage everyone towards the expectation on AI fluency, which doesn't mean use it as a tech for the sake of tech. It's tech where it's useful, to have good judgment about that, and to have the mindset to be open-minded to explore and try new things.
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youtube.com
14 July
Journalist and author of The Art of Noticing; writes the newsletter The Art of Noticing (TAoN) on attention, creativity and the everyday.
Their words
He's particularly insightful and inspiring on the natural world, so I was excited to hear about his latest book, Unwilded.
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robwalker.substack.com
14 June
Founder and former CEO of Zynga, the social-games company behind FarmVille, Zynga Poker and Words with Friends; says he founded ten companies in all, and wrote Life at the Speed of Play.
Their words
if if I got to pick one if I get to pick one thing that you do as CEO, I'm going to pick that you're right. So even if you don't, you know, even if you don't operate the ship or the factory that well, I'd rather that you picked the right product, the right strategy than you were phenomenal at execution or inspiring people or managing because, you know, being in the right body of water matters more than the right boat.
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youtube.com
8 May
Geneticist at Harvard; reads ancient DNA to work out how populations moved and mixed, and wrote Who We Are and How We Got Here.
Their words
Uh and 98% of it is other factors, especially genetic drift. So it's overwhelmingly migrations and population structure causing fluctuations in frequency.
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youtube.com
13 April
Polyglot who speaks twenty languages and co-founded LingQ; argues that comprehensible input, not study, is what does the work.
3 April
Software entrepreneur who bootstrapped and sold FeedbackPanda and now builds Podscan; writes The Bootstrapped Founder.
23 March
Hosts the Lex Fridman Podcast — long, unhurried conversations with scientists, engineers and public figures. Several of the interviews quoted elsewhere on this site are episodes of it.
Here's my conversation with Jensen Huang, CEO of NVIDIA, the most valuable & one of the most influential companies in the history of human civilization. It is the engine powering the AI revolution. This was a fascinating & inspiring conversation, in parts super-technical on engineering of every part of the AI stack, memory, power, supply chain (TSMC, ASML, etc), in parts about leadership & psychology, and in parts personal & philosophical about life, consciousness, mortality, and human nature. It's here on X in full and is up everywhere else (see comment). Timestamps: 0:00 - Introduction 0:33… Related
22 March
Hosts the Lex Fridman Podcast — long, unhurried conversations with scientists, engineers and public figures. Several of the interviews quoted elsewhere on this site are episodes of it.
It was an honor to hang out with Jensen Huang, CEO of @nvidia, and do a long-form podcast with him. Really fun & fascinating technical deep-dive conversation on & off the mic. One of the most brilliant & thoughtful human beings I've ever met. NVIDIA is the most valuable company in the world by market cap and is the engine powering the AI revolution. Podcast probably out tomorrow (Monday) unless I get stuck in too many interesting conversations while running around in SF ;-) PS: I haven't checked my messages in days. Sorry for slow replies 🙏 Trying to stay deeply focused at in overwhelmingly… Related
13 March
Irish independent game developer, maker of VVVVVV, Super Hexagon and Dicey Dungeons.
Blown away by this showcase today, everything in it is so fascinating and inspiring. I wanna make more games that are like this: youtube.com
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11 March
Hosts the Lex Fridman Podcast — long, unhurried conversations with scientists, engineers and public figures. Several of the interviews quoted elsewhere on this site are episodes of it.
Here's my conversation with Jeff Kaplan, a legendary Blizzard game designer of World of Warcraft and Overwatch, which are two of the biggest, most influential games ever made. Jeff is one of the most genuine & awesome human beings I've ever met: kind, thoughtful, hilarious, and still & forever a gamer through and through. This was a truly fun & inspiring conversation. We talk about it all: the lows, the highs, the memes, the details of the game design process, and the new game he's been secretely working on: The Legend of California. I got a chance to play the game with Jeff, and it's incredi… Related
30 January
Software entrepreneur who bootstrapped and sold FeedbackPanda and now builds Podscan; writes The Bootstrapped Founder.
Follow Your Passion (But Not Like That) Reading Time: 6 minutesA while ago, I asked my Twitter friends to tell me what the most annoying and most infuriating piece of entrepreneurial advice is that they ever received. And overwhelmingly, “follow your passion”…
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7 January
Executive coach for product leaders. Previously a partner at GV (Google Ventures) and a product manager at Google. Writes at Bring the Donuts, including a standing essential-reading list for product managers.
Their words
Claire has been a senior executive at Google and Stripe. Here she offers up a guide to leadership that is both practical and inspiring. Suitable for leaders of all levels.
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bringthedonuts.com
23 October 2025
Polyglot and language coach; teaches translating back and forth from a text as the core exercise.
3 September 2025
Founded CD Baby in 1998 and sold it in 2008, giving the proceeds to a charitable trust for music education. Since then a writer and speaker: five books and 550+ articles, published first at sive.rs, which they hand-code and keep free of advertising.
Their words
Tweets from 1765-1799 by a 4’9” hunchback physicist, friends with Goethe and Kant, admired by Nietzsche, Schopenhauer, etc. Such wonderful random thoughts, beautiful perspectives on thinking for yourself, observing nature, language, freedom, philosophy, religion, and more. Hundreds of initial insights, especially inspiring because they’re undeveloped.
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sive.rs
23 March 2025
Founder and chief executive of Superhuman, the email client; previously founder of Rapportive, which he sold to LinkedIn; a professional game designer before that.
Their words
I then asked myself, is the position of speed unique? and is it available? And the answer was overwhelmingly yes because almost no software was being sold or has ever been sold on the value proposition of speed.
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youtube.com
21 March 2025
Writer and former McKinsey/BCG strategy consultant; author of The Pathless Path and Good Work, about leaving the default career track. Publishes the Boundless newsletter and podcast.
Their words
This book is a short but inspiring take on living life on your terms while being pragmatic about money and how to make it happen. Reminds me of a less travel-centric Vagabonding.
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pathlesspath.com
18 June 2024
Language mentor and polyglot; teaches people to design their own learning method rather than follow a course.
7 May 2024
Research scientist at Anthropic; co-creator of the Variational Autoencoder and, with Jimmy Ba, of the Adam optimizer, two of the most widely used tools in deep learning.
Thanks to the ICLR Award Committee! And thank you for the kind words, Max! You were the perfect Ph.D. advisor and collaborator, kind and inspiring. I really couldn't have wished for better. Quoting @wellingmax Thank you Yisong and the Award Committee for choosing the VAE for the Test of Time award. I like to congratulate Durk who was my first (brilliant) student when moving back to the Netherlands and who is the main architect of the VAE. It was absolutely fantastic working with him. Related
12 January 2024
American author of The Obstacle Is the Way, Ego Is the Enemy and Stillness Is the Key. Writes the Reading List book-recommendation email (started 2008) and owns The Painted Porch bookstore in Bastrop, Texas. Hosts The Daily Stoic podcast.
Their words
Ann Wroe’s biography of Pontius Pilate, the Roman governor of Judaea–the man who sentenced Jesus to his gruesome death–was so overwhelmingly good that I could only read a couple pages at a time.
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ryanholiday.net
23 June 2023
Machine-learning researcher; has written the Lil'Log survey posts on how a model technique works since 2017, and worked at OpenAI from 2018 to 2024, latterly leading its safety systems team.
LLM Powered Autonomous Agents Building agents with LLM (large language model) as its core controller is a cool concept. Several proof-of-concepts demos, such as AutoGPT, GPT-Engineer and BabyAGI, serve as inspiring examples. The potentiality of LLM…
LLMs Related
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