Jennifer Gunter

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21 October

Jennifer GunterKorrents 21 Oct

From one piece Testosterone and Heart Disease 2 beliefs, in the piece's order there

korrents.com
The latest testosterone abstract does not prove that testosterone causes heart disease in postmenopausal women.

Their words

This latest testosterone abstract does not prove that testosterone causes heart disease in postmenopausal women, just as last year's estrogen abstract did not prove that hormone therapy prevents disease in perimenopause.

Testosterone and Heart Diseasevajenda.substack.com
korrents.com
Studies using the TriNetX database are not reliable enough to determine causal effects of testosterone.

Their words

Studies using the TriNexT database have too many issues to be highly reliable regarding causal effects of testosterone.

Testosterone and Heart Diseasevajenda.substack.com

16 October

Jennifer GunterKorrents 16 Oct

From one piece The Price of a Hot Flash 3 beliefs, in the piece's order there

korrents.com
Demoting drugs to a lower tier based on cost can create a self-fulfilling prophecy regarding their clinical use.

designmanagement

Their words

Demoting a drug to a third tier based on cost becomes a self-fulfilling prophecy, as many insurers and pharmacy benefit managers look at these tiers to design coverage or as excuses to exclude the more expensive drugs.

The Price of a Hot Flashvajenda.substack.com
korrents.com
The ACP guideline's exclusion of tibolone lacks sufficient evidence to justify safety concerns.

Their words

The guideline excluded tibolone for what the authors write are "safety reasons," but they provide no analysis showing why its safety profile would preclude its use for hot flashes and night sweats.

The Price of a Hot Flashvajenda.substack.com
korrents.com
Clinical guidelines can influence insurance coverage and drug pricing.

management

Their words

While guidelines don't compel anyone, they can influence insurers, pharmacy benefit managers, or governments to cover therapies and may also affect the price.

The Price of a Hot Flashvajenda.substack.com

13 September

Jennifer GunterKorrents 13 Sept

From one piece Bone Health Without the Hype 2 beliefs, in the piece's order there

korrents.com
Denosumab requires continuous use because stopping it can lead to rapid bone loss.

Their words

Denosumab is a fantastic antiresorptive medication, but people need to be on it continuously and cannot just stop it as rapid loss of bone in the 12 months after stopping can occur.

Bone Health Without the Hypevajenda.substack.com
korrents.com
Bone loss during perimenopause is likely caused by multiple hormones.

Their words

Bone loss during perimenopause is likely a multi-hormone event.

Bone Health Without the Hypevajenda.substack.com

4 September

Jennifer GunterKorrents 4 Sept

From one piece The Problem with Compounded Testosterone 3 beliefs, in the piece's order there

korrents.com
The amount of testosterone in compounded gels and creams can vary substantially from the prescribed concentration.

Their words

The one study we have showed that the amount of testosterone in compounded gels and creams can vary substantially from the prescribed concentration, which is not unexpected.

The Problem with Compounded Testosteronevajenda.substack.com
korrents.com
There are no regulations in the United States and Canada requiring compounders to prove their products contain what they claim or that they work.

America

Their words

In the United States and Canada, there are no regulations requiring compounders to prove that what they make contains what it claims or that it actually works.

The Problem with Compounded Testosteronevajenda.substack.com
korrents.com
Compounded testosterone products for women may not be formulated consistently or match their labeling.

Their words

Women who are using compounded testosterone have every reason to worry that their products may not be formulated consistently or match the labeling.

The Problem with Compounded Testosteronevajenda.substack.com

28 August

Jennifer GunterKorrents 28 Aug

From one piece Before You Share That New "HRT Prevents Dementia" Study, Read the Fine Print 3 beliefs, in the piece's order there

korrents.com
The UK Biobank is not a representative sample of the general U.K. population.

Their words

People in the UK Biobank are overall healthier than the general U.K. population, so it is not a representative sample of people on or off MHT.

vajenda.substack.com
korrents.com
Observational studies of MHT can be biased by the healthy-user effect.

Their words

One big reason is that healthier, wealthier women tend to use MHT, which creates a meaningful difference between MHT users and non-users, so we must be careful when attributing any benefit to MHT rather than to the healthy-user effect.

vajenda.substack.com
korrents.com
The results of the Squires et al. study suggest that MHT is not broadly neuroprotective.

dementia

Their words

The results are precisely the pattern that argues AGAINST broad use of MHT to prevent dementia. The women who benefited the most had shorter reproductive years or surgical menopause, which, if the results of the study are true (and we can't know if they are as it is observational...and we will get into all the issues with the UK Biobank and MHT studies shortly), they support the conclusion that MHT is NOT broadly neuroprotective.

vajenda.substack.com

30 July

Jennifer GunterKorrents 30 Jul

From one piece MIDI and the Making of Female Testosterone Deficiency 3 beliefs, in the piece's order there

korrents.com
Studies have not demonstrated a meaningful benefit of using testosterone therapy outside of sexual desire disorders.

Psychotherapy

Their words

Outside of sexual desire disorders, studies have not demonstrated a meaningful benefit of using testosterone therapy.

vajenda.substack.com
korrents.com
Testosterone levels do not reliably distinguish women with symptoms from those without.

Their words

Testosterone levels do not reliably distinguish women with symptoms from those without.

vajenda.substack.com
korrents.com
There is no established clinical syndrome or testosterone level that defines testosterone deficiency for women.

Their words

The Endocrine Society (2014) and the Global Consensus Statement on Testosterone (2019) both concluded there is no established clinical syndrome or testosterone level that defines testosterone deficiency for women.

vajenda.substack.com

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