Elliot Hershberg

From one piece CSHL: AI in Biology 3 beliefs, in the piece's order there

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  Computer science has already revolutionized biological research.

  Their words

  In other words, computer science has already revolutionized biological research.

  CSHL: AI in Biologycenturyofbio.com

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  Agentic AI systems for autonomously carrying out scientific research are still at a very early stage of development.

  Their words

  We are very early in the development of agentic systems in biology.

  CSHL: AI in Biologycenturyofbio.com

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  AI is becoming the next major paradigm shift in biology, following genetics and genomics.

  Their words

  It's becoming more clear each day that the next chapter of this story is AI.

  CSHL: AI in Biologycenturyofbio.com

From one piece AI Versus Eroom's Law 3 beliefs, in the piece's order there

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  When pharmaceutical companies act as top-down gatekeepers for which therapeutic ideas get pursued, promising innovations from startups can be overlooked.

  startupsPsychotherapyinnovation

  Their words

  Relying on pharma as top-down tastemakers can stifle the emergence of new therapeutic ideas from startups.

  AI Versus Eroom's Lawcenturyofbio.com

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  New technologies can meaningfully improve R&D productivity in drug development.

  Their words

  New technologies can and do make an impact on R&D productivity.

  AI Versus Eroom's Lawcenturyofbio.com

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  Biotech R&D efficiency and pharma R&D efficiency are not the same thing and should not be conflated.

  Their words

  Biotech R&D efficiency and pharma R&D efficiency are not the same thing.

  AI Versus Eroom's Lawcenturyofbio.com

From one piece Going Founder Mode On Cancer 3 beliefs, in the piece's order there

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  Cancer can usefully be understood as a disease of corrupted or lost genomic information.

  Their words

  Cancer is a disease of information. Loss of genomic information threatens to destroy the self.

  Going Founder Mode On Cancercenturyofbio.com

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  China's more permissive posture toward testing experimental medicines threatens the competitiveness of the American biotech industry.

  ChinaAmerica

  Their words

  In recent years, China has adopted a dramatically different posture towards testing experimental medicines that now threatens the future competitiveness of the American biotech sector.

  Going Founder Mode On Cancercenturyofbio.com

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  Drug discovery has become less efficient over time despite continued technological progress.

  Their words

  Drug discovery has gotten less efficient over time despite extraordinary technological progress.

  Going Founder Mode On Cancercenturyofbio.com

From one piece On AI Infrastructure in Biology 3 beliefs, in the piece's order there

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  AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points.

  Their words

  Compared to experiments, AI models have a few advantages: They can average out background experimental noise, incorporate priors from massive data sets like the PDB, and interpolate between nearby data points.

  On AI Infrastructure in Biologycenturyofbio.com

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  In a platform shift, no single platform company can offer every solution the next wave of applications needs.

  Their words

  In this type of transition, it's incredibly hard for one platform company to offer every solution needed to build the next wave of applications.

  On AI Infrastructure in Biologycenturyofbio.com

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  AI infrastructure companies that sell tools rather than drugs can become massive, highly valuable businesses in biotech.

  infrastructure

  Their words

  But I don't think that means there can't be massive, objectively investable infrastructure businesses that create a lot of value for the industry.

  On AI Infrastructure in Biologycenturyofbio.com

From one piece What Are Virtual Cells? 3 beliefs, in the piece's order there

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  Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli.

  Their words

  For human cells, with billions of DNA base pairs and tens of thousands of genes, the timeline for mechanistic whole-cell models is much less certain.

  What Are Virtual Cells?centuryofbio.com

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  Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence.

  protein structure prediction

  Their words

  After decades of research-including lots of attempted math and software 1.0-the problem of 3D protein structure prediction was effectively solved by deep learning.

  What Are Virtual Cells?centuryofbio.com

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  Unlike physics, biology's complexity and nonlinearity make a brute-force approach to knowledge creation necessary rather than one based on writing down equations.

  physics

  Their words

  Molecular biology is not like physics. The complexity-and nonlinearity-of living systems has required a brute force approach to knowledge creation and dissemination.

  What Are Virtual Cells?centuryofbio.com

From one piece On Modality Commoditization 3 beliefs, in the piece's order there

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  Revolutionary ideas eventually become universal building blocks for the next wave of innovation.

  innovation

  Their words

  Over time, revolutionary ideas become universal building blocks for the next wave of innovation.

  On Modality Commoditizationcenturyofbio.com

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  No technology, including drug discovery technologies, is immune to the eventual pull toward commoditization.

  Their words

  no discovery technology is immune from the inescapable pull towards commoditization-like virtually every other technology.

  On Modality Commoditizationcenturyofbio.com

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  China has become a serious competitive threat in biotech, capable of developing drugs that rival or surpass those produced in American labs.

  ChinaAmerica

  Their words

  China has become a serious competitive threat in biotech, demonstrating the capacity to rapidly develop new drugs that can rival-or surpass-those being produced in American labs.

  On Modality Commoditizationcenturyofbio.com

From one piece Hub-and-Spoke Biotechs: BridgeBio 3 beliefs, in the piece's order there

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  The Human Genome Project's results have been less transformative than initially advertised relative to its cost.

  Their words

  I think this partially explains some of the discontent in the scientific community about the Human Genome Project. After billions of dollars that could have been spent in other places, the result is less transformative than initially advertised.

  Hub-and-Spoke Biotechs: BridgeBiocenturyofbio.com

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  The number of diseases with a known molecular explanation has grown far faster than the number of new drugs developed to treat them.

  Their words

  The set of diseases for which we have a molecular explanation-which resembles the equivalent of the Craigslist homepage for this analogy-has grown far faster than the corresponding set of new drugs to treat them.

  Hub-and-Spoke Biotechs: BridgeBiocenturyofbio.com

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  The biotech industry has not undergone the same exhaustive search for every commercializable opportunity that followed the internet's growth boom.

  Their words

  What we haven't seen is the same type of frantic hunt for every nugget of value that could be commercialized as a result of this enormous secular trend.

  Hub-and-Spoke Biotechs: BridgeBiocenturyofbio.com